TY - JOUR
T1 - Functional Segregation of Cortical Regions Underlying Speech Timing and Articulation
AU - Long, Michael A.
AU - Katlowitz, Kalman A.
AU - Svirsky, Mario A.
AU - Clary, Rachel C.
AU - Byun, Tara Mc Allister
AU - Majaj, Najib
AU - Oya, Hiroyuki
AU - Howard, Matthew A.
AU - Greenlee, Jeremy D.W.
N1 - Funding Information:
We thank all of the patient volunteers for their contributions to this project. Haiming Chen and Theo John Franklin Di Castri contributed research support for this project. Daniel Szeredi helped us with the software necessary to implement our crowdsourcing procedure. We acknowledge valuable discussions with David Poeppel and Daryush Mehta, and we thank Richard Tsien, David Poeppel, Kristopher Bouchard, Kristina Simonyan, Daniela Vallentin, and Georg Kosche for their comments on an earlier version of this manuscript. A talented team of neurosurgical residents at the University of Iowa Hospitals and Clinics assisted with data collection, including Adam Jackson and Daniel Hansen. This work was supported by the NIH (DC004290, DC009589, and NS075044), the G. Harold & Leila Y. Mathers Charitable Foundation, and the NYSC Foundation.
Funding Information:
We thank all of the patient volunteers for their contributions to this project. Haiming Chen and Theo John Franklin Di Castri contributed research support for this project. Daniel Szeredi helped us with the software necessary to implement our crowdsourcing procedure. We acknowledge valuable discussions with David Poeppel and Daryush Mehta, and we thank Richard Tsien, David Poeppel, Kristopher Bouchard, Kristina Simonyan, Daniela Vallentin, and Georg Kosche for their comments on an earlier version of this manuscript. A talented team of neurosurgical residents at the University of Iowa Hospitals and Clinics assisted with data collection, including Adam Jackson and Daniel Hansen. This work was supported by the NIH (DC004290, DC009589, and NS075044), the G. Harold & Leila Y. Mathers Charitable Foundation, and the NYSC Foundation.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/3/16
Y1 - 2016/3/16
N2 - Spoken language is a central part of our everyday lives, but the precise roles that individual cortical regions play in the production of speech are often poorly understood. To address this issue, we focally lowered the temperature of distinct cortical regions in awake neurosurgical patients, and we relate this perturbation to changes in produced speech sequences. Using this method, we confirm that speech is highly lateralized, with the vast majority of behavioral effects seen on the left hemisphere. We then use this approach to demonstrate a clear functional dissociation between nearby cortical speech sites. Focal cooling of pars triangularis/pars opercularis (Broca's region) and the ventral portion of the precentral gyrus (speech motor cortex) resulted in the manipulation of speech timing and articulation, respectively. Our results support a class of models that have proposed distinct processing centers underlying motor sequencing and execution for speech.
AB - Spoken language is a central part of our everyday lives, but the precise roles that individual cortical regions play in the production of speech are often poorly understood. To address this issue, we focally lowered the temperature of distinct cortical regions in awake neurosurgical patients, and we relate this perturbation to changes in produced speech sequences. Using this method, we confirm that speech is highly lateralized, with the vast majority of behavioral effects seen on the left hemisphere. We then use this approach to demonstrate a clear functional dissociation between nearby cortical speech sites. Focal cooling of pars triangularis/pars opercularis (Broca's region) and the ventral portion of the precentral gyrus (speech motor cortex) resulted in the manipulation of speech timing and articulation, respectively. Our results support a class of models that have proposed distinct processing centers underlying motor sequencing and execution for speech.
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U2 - 10.1016/j.neuron.2016.01.032
DO - 10.1016/j.neuron.2016.01.032
M3 - Article
C2 - 26924439
AN - SCOPUS:84960798539
VL - 89
SP - 1187
EP - 1193
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 6
ER -