TY - CHAP
T1 - G protein-coupled receptor trafficking and signalling in the enteric nervous system
T2 - The past, present and future
AU - Poole, Daniel P.
AU - Bunnett, Nigel W.
N1 - Funding Information:
Supported by: NHMRC 454858 & 1049730 (DPP), NHMRC 63303, 1049682, 1031886 and Monash University (NWB).
Publisher Copyright:
© Springer International Publishing Switzerland 2016.
PY - 2016
Y1 - 2016
N2 - G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell’s ability to respond to subsequent exposure to agonists.
AB - G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell’s ability to respond to subsequent exposure to agonists.
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U2 - 10.1007/978-3-319-27592-5_14
DO - 10.1007/978-3-319-27592-5_14
M3 - Chapter
C2 - 27379642
AN - SCOPUS:84992504774
T3 - Advances in Experimental Medicine and Biology
SP - 145
EP - 152
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -