G protein-coupled receptor trafficking and signalling in the enteric nervous system: The past, present and future

Daniel P. Poole, Nigel W. Bunnett

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

G protein-coupled receptors (GPCRs) enable cells to detect and respond to changes in their extracellular environment. With over 800 members, the GPCR family includes receptors for a diverse range of agonists including olfactants, neurotransmitters and hormones. Importantly, GPCRs represent a major therapeutic target, with approximately 50 % of all current drugs acting at some aspect of GPCR signalling (Audet and Bouvier 2008). GPCRs are widely expressed by all cell types in the gastrointestinal (GI) tract and are major regulators of every aspect of gut function. Many GPCRs are internalised upon activation, and this represents one of the mechanisms through which G protein-signalling is terminated. The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell’s ability to respond to subsequent exposure to agonists.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages145-152
Number of pages8
DOIs
StatePublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume891
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Poole, D. P., & Bunnett, N. W. (2016). G protein-coupled receptor trafficking and signalling in the enteric nervous system: The past, present and future. In Advances in Experimental Medicine and Biology (pp. 145-152). (Advances in Experimental Medicine and Biology; Vol. 891). Springer New York LLC. https://doi.org/10.1007/978-3-319-27592-5_14