GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients

Ji Won Bang, Carlos Parra, Kevin Yu, Gadi Wollstein, Joel S. Schuman, Kevin C. Chan

Research output: Contribution to journalArticlepeer-review


Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic mechanisms and neurobehavioral relevance remain largely unclear. Here, using proton magnetic resonance spectroscopy and functional magnetic resonance imaging, we investigated the GABAergic and glutamatergic systems in the visual cortex of glaucoma patients, as well as neural specificity, which is shaped by GABA and glutamate signals and underlies efficient sensory and cognitive functions. Our study shows that among the older adults, both GABA and glutamate levels decrease with increasing glaucoma severity regardless of age. Further, our study shows that the reduction of GABA but not glutamate predicts the neural specificity. This association is independent of the impairments on the retina structure, age, and the gray matter volume of the visual cortex. Our results suggest that glaucoma-specific decline of GABA undermines neural specificity in the visual cortex and that targeting GABA could improve the neural specificity in glaucoma.

Original languageEnglish (US)
Article number679
JournalCommunications Biology
Issue number1
StatePublished - Dec 2023

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


Dive into the research topics of 'GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients'. Together they form a unique fingerprint.

Cite this