GABAB receptor modulation of synaptic function

Jason R. Chalifoux, Adam G. Carter

Research output: Contribution to journalReview articlepeer-review


Neuromodulators have complex effects on both the presynaptic release and postsynaptic detection of neurotransmitters. Here we describe recent advances in our understanding of synaptic modulation by metabotropic GABAB receptors. By inhibiting multivesicular release from the presynaptic terminal, these receptors decrease the synaptic glutamate signal. GABAB receptors also inhibit the Ca2+ permeability of NMDA receptors to decrease Ca2+ signals in postsynaptic spines. These new findings highlight the importance of GABAB receptors in regulating many aspects of synaptic transmission. They also point to novel questions about the spatiotemporal dynamics and sources of synaptic modulation in the brain.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number2
StatePublished - Apr 2011

ASJC Scopus subject areas

  • General Neuroscience


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