Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study

Suman Tandon, Frans J.T. Wackers, Silvio E. Inzucchi, Shanti Bansal, Lawrence H. Staib, Deborah A. Chyun, Janice A. Davey, Lawrence H. Young

Research output: Contribution to journalArticle

Abstract

Gender differences in cardiovascular outcomes were compared in asymptomatic men and women with type 2 diabetes (T2DM) in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) study. Of 1123 participants, 290 men and 271 women were randomised to screening with stress myocardial perfusion imaging (MPI); 311 men and 251 women wererandomised to no screening. Follow-up was 4.8±0.9 years for the occurrence of cardiac events (CE; cardiac death or non-fatal myocardial infarction). The frequency of abnormal screening was similar in men (24%) and women (19%), (p=0.2), although women trended to have smaller MPI abnormalities. CE rates were lower in women than men (1.7% vs. 3.8%, p=0.04). No CEs occurred in 17 high-risk (UKPDS risk engine) women, whereas 14 (11.2%) occurred in 125 highrisk men. Asymptomatic women with T2DM have significantly better cardiac outcomes than their male counterparts andrepresent a subgroup for which screening for coronary artery disease does not appear warranted.

Original languageEnglish (US)
Pages (from-to)124-130
Number of pages7
JournalDiabetes and Vascular Disease Research
Volume9
Issue number2
DOIs
StatePublished - Apr 2012

Keywords

  • Cardiovascular outcomes
  • Gender differences
  • Screening
  • Silent coronary artery disease
  • Stress myocardial perfusion imaging
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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