Gender differences in smoking cessation in a placebo-controlled trial of bupropion with behavioral counseling

Bradley N. Collins, E. Paul Wileyto, Freda Patterson, Margaret Rukstalis, Janet Audrain-McGovern, Vyga Kaufmann, Angela Pinto, Larry Hawk, Raymond Niaura, Leonard H. Epstein, Caryn Lerman

Research output: Contribution to journalArticlepeer-review


Among smokers, women may be at greater risk than men for developing smoking-related diseases, perhaps because they have greater difficulty quitting smoking, as suggested by numerous studies. In the present study, we hypothesized that bupropion would reduce this gender disparity among 314 women and 241 men enrolled in a placebo-controlled, randomized trial using behavioral counseling plus 10 weeks of bupropion (300 mg). Prolonged abstinence and biochemically verified point prevalence outcomes were measured at end of treatment (8 weeks after the quit date) and at 6-month follow-up. A logistic regression model of 6-month prolonged abstinence and a Cox regression (survival analysis) model revealed a significant gender by smoking rate by drug interaction and a main effect for marital status. This three-way interaction suggests that bupropion particularly benefited men who smoked more than one pack of cigarettes per day at baseline and, conversely, women who smoked a pack or less. The point prevalence logistic regression model showed no evidence that either gender or smoking rate modified the effect of treatment. These results suggest that bupropion treatment may reduce the gender disparity in prolonged abstinence rates among lighter smokers.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalNicotine and Tobacco Research
Issue number1
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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