Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh

F. Wu; M. L. Liu; X. Cheng; J. Y. Jiang; Y. Chen; F. Parvez; V. Slavkovich; D. Levy; J. H. Graziano; F. Jasmine; M. G. Kibriya; H. Ahsan; T. Islam; A. Ahmed; M. Rakibuz-Zaman; S. Roy; R. Paul-Brutus

doi:10.1201/b16767-226

Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh

F. Wu, M. L. Liu, X. Cheng, J. Y. Jiang, Y. Chen, F. Parvez, V. Slavkovich, D. Levy, J. H. Graziano, F. Jasmine, M. G. Kibriya, H. Ahsan, T. Islam, A. Ahmed, M. Rakibuz-Zaman, S. Roy, R. Paul-Brutus

Urban Initiative

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Arsenic exposure from drinking water has been linked to subclinical and clinical outcomes of cardiovascular disease (CVD). However, no large-scale studies have evaluated whether the cardiovascular effects of arsenic exposure could be modified by genetic factors. Using data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we evaluated whether the association between arsenic exposure and CVD risk or carotid artery Intima-Media Thickness (cIMT) differs by single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, and inflammation and endothelial dysfunction. We found significant interactions between well-water As and two SNPs in ICAM1 and VCAM1 in CVD risk, and of both well-water As and urinary As with 3 SNPs in AS3MT in cIMT. Our data provide novel evidence that the cardiovascular effects of arsenic exposure may vary with some common genetic variants in genes related to arsenic metabolism and endothelial dysfunction.

Original language	English (US)
Title of host publication	One Century of the Discovery of Arsenicosis in Latin America (1914-2014)
Subtitle of host publication	As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
Publisher	CRC Press/Balkema
Pages	610-612
Number of pages	3
ISBN (Print)	9781138001411
DOIs	https://doi.org/10.1201/b16767-226
State	Published - 2014
Event	5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina Duration: May 11 2014 → May 16 2014

Publication series

Name	One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

Other

Other	5th International Congress on Arsenic in the Environment, As 2014
Country/Territory	Argentina
City	Buenos Aires
Period	5/11/14 → 5/16/14

ASJC Scopus subject areas

Chemical Health and Safety

Access to Document

10.1201/b16767-226

Cite this

Wu, F., Liu, M. L., Cheng, X., Jiang, J. Y., Chen, Y., Parvez, F., Slavkovich, V., Levy, D., Graziano, J. H., Jasmine, F., Kibriya, M. G., Ahsan, H., Islam, T., Ahmed, A., Rakibuz-Zaman, M., Roy, S., & Paul-Brutus, R. (2014). Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 610-612). (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment). CRC Press/Balkema. https://doi.org/10.1201/b16767-226

Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh. / Wu, F.; Liu, M. L.; Cheng, X. et al.
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 610-612 (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wu, F, Liu, ML, Cheng, X, Jiang, JY, Chen, Y, Parvez, F, Slavkovich, V, Levy, D, Graziano, JH, Jasmine, F, Kibriya, MG, Ahsan, H, Islam, T, Ahmed, A, Rakibuz-Zaman, M, Roy, S & Paul-Brutus, R 2014, Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh. in One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment, CRC Press/Balkema, pp. 610-612, 5th International Congress on Arsenic in the Environment, As 2014, Buenos Aires, Argentina, 5/11/14. https://doi.org/10.1201/b16767-226

Wu F, Liu ML, Cheng X, Jiang JY, Chen Y, Parvez F et al. Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema. 2014. p. 610-612. (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment). doi: 10.1201/b16767-226

Wu, F. ; Liu, M. L. ; Cheng, X. et al. / Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. pp. 610-612 (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

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abstract = "Arsenic exposure from drinking water has been linked to subclinical and clinical outcomes of cardiovascular disease (CVD). However, no large-scale studies have evaluated whether the cardiovascular effects of arsenic exposure could be modified by genetic factors. Using data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we evaluated whether the association between arsenic exposure and CVD risk or carotid artery Intima-Media Thickness (cIMT) differs by single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, and inflammation and endothelial dysfunction. We found significant interactions between well-water As and two SNPs in ICAM1 and VCAM1 in CVD risk, and of both well-water As and urinary As with 3 SNPs in AS3MT in cIMT. Our data provide novel evidence that the cardiovascular effects of arsenic exposure may vary with some common genetic variants in genes related to arsenic metabolism and endothelial dysfunction.",

author = "F. Wu and Liu, {M. L.} and X. Cheng and Jiang, {J. Y.} and Y. Chen and F. Parvez and V. Slavkovich and D. Levy and Graziano, {J. H.} and F. Jasmine and Kibriya, {M. G.} and H. Ahsan and T. Islam and A. Ahmed and M. Rakibuz-Zaman and S. Roy and R. Paul-Brutus",

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AU - Kibriya, M. G.

AU - Ahsan, H.

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N2 - Arsenic exposure from drinking water has been linked to subclinical and clinical outcomes of cardiovascular disease (CVD). However, no large-scale studies have evaluated whether the cardiovascular effects of arsenic exposure could be modified by genetic factors. Using data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we evaluated whether the association between arsenic exposure and CVD risk or carotid artery Intima-Media Thickness (cIMT) differs by single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, and inflammation and endothelial dysfunction. We found significant interactions between well-water As and two SNPs in ICAM1 and VCAM1 in CVD risk, and of both well-water As and urinary As with 3 SNPs in AS3MT in cIMT. Our data provide novel evidence that the cardiovascular effects of arsenic exposure may vary with some common genetic variants in genes related to arsenic metabolism and endothelial dysfunction.

AB - Arsenic exposure from drinking water has been linked to subclinical and clinical outcomes of cardiovascular disease (CVD). However, no large-scale studies have evaluated whether the cardiovascular effects of arsenic exposure could be modified by genetic factors. Using data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we evaluated whether the association between arsenic exposure and CVD risk or carotid artery Intima-Media Thickness (cIMT) differs by single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, and inflammation and endothelial dysfunction. We found significant interactions between well-water As and two SNPs in ICAM1 and VCAM1 in CVD risk, and of both well-water As and urinary As with 3 SNPs in AS3MT in cIMT. Our data provide novel evidence that the cardiovascular effects of arsenic exposure may vary with some common genetic variants in genes related to arsenic metabolism and endothelial dysfunction.

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Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh

Abstract

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ASJC Scopus subject areas

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