Gene-level quantitative trait mapping in Caenorhabditis elegans

Luke M. Noble, Matthew V. Rockman, Henrique Teotónio

Research output: Contribution to journalArticlepeer-review

Abstract

The Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel is a collection of genome-sequenced, cryopreserved recombinant inbred lines useful for mapping the evolution and genetic basis of quantitative traits. We have expanded the resource with new lines and new populations, and here report the genotype and haplotype composition of CeMEE version 2, including a large set of putative de novo mutations, and updated additive and epistatic mapping simulations. Additive quantitative trait loci explaining 4% of trait variance are detected with >80% power, and the median detection interval approaches single-gene resolution on the highly recombinant chromosome arms. Although CeMEE populations are derived from a long-term evolution experiment, genetic structure is dominated by variation present in the ancestral population.

Original languageEnglish (US)
Article numberjkaa061
JournalG3: Genes, Genomes, Genetics
Volume11
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Complex trait
  • Experimental evolution
  • Genetic architecture
  • MPP
  • Multiparent Advanced Generation Inter-Cross (MAGIC)
  • Multiparental populations
  • QTL
  • Quantitative trait

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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