@inbook{7e66ca3a88204d75a6a5302ac9f943b2,
title = "Gene regulatory networks during the development of the Drosophila visual system",
abstract = "The Drosophila visual system integrates input from 800 ommatidia and extracts different features in stereotypically connected optic ganglia. The development of the Drosophila visual system is controlled by gene regulatory networks that control the number of precursor cells, generate neuronal diversity by integrating spatial and temporal information, coordinate the timing of retinal and optic lobe cell differentiation, and determine distinct synaptic targets of each cell type. In this chapter, we describe the known gene regulatory networks involved in the development of the different parts of the visual system and explore general components in these gene networks. Finally, we discuss the advantages of the fly visual system as a model for gene regulatory network discovery in the era of single-cell transcriptomics.",
keywords = "Drosophila visual system, Fate specification, Gene regulatory network, Neural diversity, Drosophila/classification, Eye/embryology, Gene Regulatory Networks, Retina/cytology, Animals, Gene Expression Regulation, Developmental, Drosophila melanogaster/embryology, Embryo, Nonmammalian/cytology, Cell Differentiation/genetics, Optic Lobe, Nonmammalian/cytology",
author = "Chen, {Yen Chung} and Claude Desplan",
note = "Funding Information: We would like to thank Nikolaos Konstantinides, Ne{\c s}et {\"O}zel, Filipe Pinto-Teixeira, Anthony Rossi, F{\'e}lix Simon, and Jessica Treisman for discussions and input. We also want to apologize to the researchers whose work contributed to our current understanding of the development of the Drosophila visual system but could not be included in this review. This work was supported by a grant from NIH R01 EY13010. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
doi = "10.1016/bs.ctdb.2020.02.010",
language = "English (US)",
volume = "139",
series = "Current topics in developmental biology",
publisher = "Academic Press Inc.",
pages = "89--125",
booktitle = "Gene Regulatory Networks",
address = "United States",
}