TY - JOUR
T1 - Gene synteny in species of Plasmodium
AU - Carlton, J. M R
AU - Vinkenoog, Rinke
AU - Waters, Andrew P.
AU - Walliker, David
N1 - Funding Information:
We thank Chris Janse for valuable advice and assistance during this project, and Don Williamson for the use of the P. falciparum EF-1 α data. We would also like to thank all those who kindly donated gene probes. Financial support is gratefully acknowledged from the Medical Research Council of Great Britain, and the INCO-DC programme of the European Community (IC18CT960052). RV was supported by a Doctor of Philosophy Award from the University of Leiden.
PY - 1998/6/1
Y1 - 1998/6/1
N2 - We have attempted to establish the degree of linkage conservation between different species of the malaria parasite Plasmodium. Initially, the chromosome locations of 42 homologous genes were established in parasites from a rodent malaria species and the human malaria parasite P. falciparum. Of these genes, 26 appeared to be conserved within ten synteny groups between the two genomes. Several synteny groups were analysed further by long-range restriction mapping of digested chromosomes. Finally, a fine restriction map of one of the linkage groups was made from the rodent malaria parasites P. berghei and from P. falciparum and from the simian malaria parasite P. knowlesi. The fine-scale organisation of this linkage group appears to have remained intact among the three species, despite the evolutionary distance between them. This provides the first example of linkage conservation between the rodent, simian and human malaria species, which represent three different branches of the inferred phylogenetic tree of the genus Plasmodium. Copyright (C) 1998 Elsevier Science B.V.
AB - We have attempted to establish the degree of linkage conservation between different species of the malaria parasite Plasmodium. Initially, the chromosome locations of 42 homologous genes were established in parasites from a rodent malaria species and the human malaria parasite P. falciparum. Of these genes, 26 appeared to be conserved within ten synteny groups between the two genomes. Several synteny groups were analysed further by long-range restriction mapping of digested chromosomes. Finally, a fine restriction map of one of the linkage groups was made from the rodent malaria parasites P. berghei and from P. falciparum and from the simian malaria parasite P. knowlesi. The fine-scale organisation of this linkage group appears to have remained intact among the three species, despite the evolutionary distance between them. This provides the first example of linkage conservation between the rodent, simian and human malaria species, which represent three different branches of the inferred phylogenetic tree of the genus Plasmodium. Copyright (C) 1998 Elsevier Science B.V.
UR - http://www.scopus.com/inward/record.url?scp=17344383488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17344383488&partnerID=8YFLogxK
U2 - 10.1016/S0166-6851(98)00043-7
DO - 10.1016/S0166-6851(98)00043-7
M3 - Article
C2 - 9662712
AN - SCOPUS:17344383488
SN - 0166-6851
VL - 93
SP - 285
EP - 294
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
IS - 2
ER -