Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS)

Sung Jae Kim, Yong Ak Song, Paul L. Skipper, Steven R. Tannenbaum, Jongyoon Han

Research output: Contribution to conferencePaperpeer-review

Abstract

We have developed a drop-on-demand microdroplet generator for the discrete dispensing of bio-samples into a bio-analytical unit, Accelerator Mass Spectrometry (AMS). The disposable PDMS microfluidic device can generate monodisperse droplets of pico-liter volume directly out of a plane sidewall of the microfluidic chip by an electrohydrodynamic mechanism. The droplet generation was accomplished without using either an inserted capillary or built-in tip. The minimum droplet volume was around 4 pico-liters, and the droplet generation was repeatable and stable for at least 30 minutes, with a typical variation of less than 2.0% of drop size. A computational simulation of the droplet generation verified the importance of controlling the surface wetting conditions for the droplet formation. Our microdroplet generator can be effective interfacing mechanism from a microfluidic chip to a non-chip bio-sensing unit, such as AMS or MALDI-MS.

Original languageEnglish (US)
Pages1076-1078
Number of pages3
StatePublished - 2006
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: Nov 5 2006Nov 9 2006

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period11/5/0611/9/06

Keywords

  • AMS
  • Drop-on-demand dispenser
  • EHD
  • Microdroplet generator
  • PDMS microchip

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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