TY - JOUR
T1 - Generation and Evolution of Neural Cell Types and Circuits
T2 - Insights from the Drosophila Visual System
AU - Perry, Michael
AU - Konstantinides, Nikos
AU - Pinto-Teixeira, Filipe
AU - Desplan, Claude
N1 - Publisher Copyright:
Copyright © 2017 by Annual Reviews. All rights reserved.
PY - 2017/11/27
Y1 - 2017/11/27
N2 - The Drosophila visual system has become a premier model for probing how neural diversity is generated during development. Recent work has provided deeper insight into the elaborate mechanisms that control the range of types and numbers of neurons produced, which neurons survive, and how they interact. These processes drive visual function and influence behavioral preferences. Other studies are beginning to provide insight into how neuronal diversity evolved in insects by adding new cell types and modifying neural circuits. Some of the most powerful comparisons have been those made to the Drosophila visual system, where a deeper understanding of molecular mechanisms allows for the generation of hypotheses about the evolution of neural anatomy and function. The evolution of new neural types contributes additional complexity to the brain and poses intriguing questions about how new neurons interact with existing circuitry. We explore how such individual changes in a variety of species might play a role over evolutionary timescales. Lessons learned from the fly visual system apply to other neural systems, including the fly central brain, where decisions are made and memories are stored.
AB - The Drosophila visual system has become a premier model for probing how neural diversity is generated during development. Recent work has provided deeper insight into the elaborate mechanisms that control the range of types and numbers of neurons produced, which neurons survive, and how they interact. These processes drive visual function and influence behavioral preferences. Other studies are beginning to provide insight into how neuronal diversity evolved in insects by adding new cell types and modifying neural circuits. Some of the most powerful comparisons have been those made to the Drosophila visual system, where a deeper understanding of molecular mechanisms allows for the generation of hypotheses about the evolution of neural anatomy and function. The evolution of new neural types contributes additional complexity to the brain and poses intriguing questions about how new neurons interact with existing circuitry. We explore how such individual changes in a variety of species might play a role over evolutionary timescales. Lessons learned from the fly visual system apply to other neural systems, including the fly central brain, where decisions are made and memories are stored.
KW - Cell fate
KW - Development
KW - Evolution
KW - Neural diversity
KW - Neuropil evolution
KW - Temporal series
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U2 - 10.1146/annurev-genet-120215-035312
DO - 10.1146/annurev-genet-120215-035312
M3 - Review article
C2 - 28961025
AN - SCOPUS:85036539402
SN - 0066-4197
VL - 51
SP - 501
EP - 577
JO - Annual Review of Genetics
JF - Annual Review of Genetics
ER -