Genetic and environmental risks for high blood pressure among african american mothers and daughters

Jacquelyn Y. Taylor, Rosanna Maddox, Wu Chun Yi

Research output: Contribution to journalArticle

Abstract

Objective: To determine the relationship between genetic and environmental lifestyle factors (physical activity and sodium) on blood pressure (BP) among African-American women. Method: In this cross-sectional study involving 108 African-American mothers and daughters from a Midwestern area, investigators obtained BP measurements, information on minutes of physical activity, amount of sodium intake, and buccal swab saliva samples. Results: Of the 4 single nucleotide polymorphisms (SNPs) on the sodium bicarbonate cotransporter gene (SLC4A5), rs8179526 had a statistically significant interaction with cytosine/thymine (C/T) genotype by sodium status on systolic BP (SBP; p =.0077). For gene - physical activity interaction, 2 significant interactions (cytosine/adenine [C/A] genotype by physical activity and adenine/adenine [A/A] genotype by physical activity, p =.0107 and p =.0171, respectively) on SBP and 1 on diastolic BP (DBP; A/A genotype by physical activity, p =.0233) were found on rs1017783. Two significant guanine/adenine [G/A] genotype by physical activity interactions were found on rs6731545 for SBP and DBP (p =.0160 and p =.0492, respectively). Discussion: A gene - environmental interaction with rs8179526 has a protective effect on SBP in African-American women with high sodium intake. Participants with C/T genotype of rs8179526 who consumed greater than 2,300 mg of sodium had lower SBP than those who consumed less than recommended. Women with thymine/thymine (T/T) genotype of rs8179526 who consumed greater than 2,300 mg had lower SBP than those who consumed less. Awareness of both the protective and deleterious properties of rs8179526 in African-American women may one day assist in determining appropriate treatment plans.

Original languageEnglish (US)
Pages (from-to)53-65
Number of pages13
JournalBiological Research for Nursing
Volume11
Issue number1
DOIs
StatePublished - Jul 2009

Keywords

  • African-American women
  • Gene-environment
  • High BP

ASJC Scopus subject areas

  • Research and Theory

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