Genetic connections of the actin cytoskeleton and beyond

Research output: Contribution to journalArticlepeer-review

Abstract

Actin is a key protein in numerous cellular functions. One recent study has identified a large set of genes, associated with the actin cytoskeleton, which could be grouped into a wide spectrum of cytoplasmic and nuclear functions, such as protein biosynthesis and gene transcription.(1) Deletions of many of the identified genes affected cellular actin organization,(1) suggesting a functional link between different actin fractions probably regulated through changes in actin dynamics. The data are very exciting; speculations on the crosstalk between cytoplasmic and nuclear actin fractions in different cellular contexts may help placing the results in perspective to further understand how actin-mediated signalling affects cellular functions, such as gene expression.

Original languageEnglish (US)
Pages (from-to)407-411
Number of pages5
JournalBioEssays
Volume29
Issue number5
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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