Genetic control of the cytolytic T lymphocyte response to influenza virus was examined. Mice bearing the H-2(b) haplotype and F1 hybrid mice derived from C57BL/6 parents failed to recognize H-2K(b) plus type A or type B influenza viruses. Congenic mice that shared H-2K(b) but had either H-2D(d) or H-2D(q) genotypes responded in in vitro secondary cultures to H-2K(b) plus virus. Mapping studies suggest the gene(s) controlling the ability to respond to H-2K(b) plus virus can be localized in or near the H-2D region. Several interpretations of these observations are discussed.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Immunology|
|State||Published - 1982|
ASJC Scopus subject areas
- Immunology and Allergy