Genetic control of the cytolytic T lymphocyte response to influenza viruses: H-2D genes influence the response to H-2K(b) plus virus

C. S. Reiss, M. E. Dorf, B. Benacerraf, S. J. Burakoff

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic control of the cytolytic T lymphocyte response to influenza virus was examined. Mice bearing the H-2(b) haplotype and F1 hybrid mice derived from C57BL/6 parents failed to recognize H-2K(b) plus type A or type B influenza viruses. Congenic mice that shared H-2K(b) but had either H-2D(d) or H-2D(q) genotypes responded in in vitro secondary cultures to H-2K(b) plus virus. Mapping studies suggest the gene(s) controlling the ability to respond to H-2K(b) plus virus can be localized in or near the H-2D region. Several interpretations of these observations are discussed.

Original languageEnglish (US)
Pages (from-to)2295-2299
Number of pages5
JournalJournal of Immunology
Volume128
Issue number5
StatePublished - 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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