Genetic counseling for prostate cancer risk

A. M. Nieder, S. S. Taneja, M. P.A. Zeegers, Harry Ostrer

    Research output: Contribution to journalReview article

    Abstract

    Major risk factors for developing prostate cancer, including positive family history and African-American ethnicity, can be quantified for genetic counseling. Factors increasing familial risk for prostate cancer are closer degree of kinship, number of affected relatives, and early age of onset (< 50 years) among the affected relatives. Genetic testing may be useful for modification of risk, but currently should be performed only within the context of a well-designed research study that will determine penetrance and genotype-phenotype correlation of specific mutations. Even in the absence of genetic testing, African-American men and men with a strong family history of prostate cancer may opt to initiate screening by prostate specific antigen (PSA) and digital rectal exam (DRE) screening at age 40.

    Original languageEnglish (US)
    Pages (from-to)169-176
    Number of pages8
    JournalClinical Genetics
    Volume63
    Issue number3
    DOIs
    StatePublished - Mar 1 2003

    Keywords

    • Genetic counseling
    • Genetic testing
    • Prostate cancer
    • Risk assessment

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

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  • Cite this

    Nieder, A. M., Taneja, S. S., Zeegers, M. P. A., & Ostrer, H. (2003). Genetic counseling for prostate cancer risk. Clinical Genetics, 63(3), 169-176. https://doi.org/10.1034/j.1399-0004.2003.00038.x