Genetic counseling for prostate cancer risk

A. M. Nieder, S. S. Taneja, M. P.A. Zeegers, Harry Ostrer

Research output: Contribution to journalReview articlepeer-review


Major risk factors for developing prostate cancer, including positive family history and African-American ethnicity, can be quantified for genetic counseling. Factors increasing familial risk for prostate cancer are closer degree of kinship, number of affected relatives, and early age of onset (< 50 years) among the affected relatives. Genetic testing may be useful for modification of risk, but currently should be performed only within the context of a well-designed research study that will determine penetrance and genotype-phenotype correlation of specific mutations. Even in the absence of genetic testing, African-American men and men with a strong family history of prostate cancer may opt to initiate screening by prostate specific antigen (PSA) and digital rectal exam (DRE) screening at age 40.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalClinical Genetics
Issue number3
StatePublished - Mar 1 2003


  • Genetic counseling
  • Genetic testing
  • Prostate cancer
  • Risk assessment

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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