Genetic network during neural crest induction: From cell specification to cell survival

Ben Steventon; Carlos Carmona-Fontaine; Roberto Mayor

doi:10.1016/j.semcdb.2005.06.001

Genetic network during neural crest induction: From cell specification to cell survival

Ben Steventon, Carlos Carmona-Fontaine, Roberto Mayor

Biology and Genomics

Research output: Contribution to journal › Review article › peer-review

Abstract

The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.

Original language	English (US)
Pages (from-to)	647-654
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.semcdb.2005.06.001
State	Published - Dec 2005

Keywords

BMP
Cell survival
FGF
Genetic cascade
Neural crest
Retinoic acid
Wnt

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2005.06.001

Cite this

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title = "Genetic network during neural crest induction: From cell specification to cell survival",

abstract = "The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a na{\"i}ve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.",

keywords = "BMP, Cell survival, FGF, Genetic cascade, Neural crest, Retinoic acid, Wnt",

author = "Ben Steventon and Carlos Carmona-Fontaine and Roberto Mayor",

note = "Funding Information: We thank Lorena Marchant for comment on the manuscript. This investigation was supported by an International Research Scholar Award from the Howard Hughes Medical Institute to R.M., and by grants from MRC and the Millennium Program (P99-137F and ICM P02-050). B.S. has a BBSRC Ph.D. fellowship. ",

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doi = "10.1016/j.semcdb.2005.06.001",

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journal = "Seminars in Cell and Developmental Biology",

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T1 - Genetic network during neural crest induction

T2 - From cell specification to cell survival

AU - Steventon, Ben

AU - Carmona-Fontaine, Carlos

AU - Mayor, Roberto

N1 - Funding Information: We thank Lorena Marchant for comment on the manuscript. This investigation was supported by an International Research Scholar Award from the Howard Hughes Medical Institute to R.M., and by grants from MRC and the Millennium Program (P99-137F and ICM P02-050). B.S. has a BBSRC Ph.D. fellowship.

PY - 2005/12

Y1 - 2005/12

N2 - The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.

AB - The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.

KW - BMP

KW - Cell survival

KW - FGF

KW - Genetic cascade

KW - Neural crest

KW - Retinoic acid

KW - Wnt

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SN - 1084-9521

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JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

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ER -

Genetic network during neural crest induction: From cell specification to cell survival

Abstract

Keywords

ASJC Scopus subject areas

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