Genetic variants linked to education predict longevity

R. E. Marioni, S. J. Ritchie, P. K. Joshi, S. P. Hagenaars, A. Okbay, K. Fischer, M. J. Adams, W. D. Hill, G. Davies, R. Nagy, C. Amador, K. Läll, A. Metspalu, D. C. Liewald, A. Campbell, J. F. Wilson, C. Hayward, T. Esko, D. J. Porteous, C. R. GaleI. J. Deary, A. Okbay, J. P. Beauchamp, M. A. Fontana, J. J. Lee, T. H. Pers, C. A. Rietveld, P. Turley, G. B. Chen, V. Emilsson, S. F. Meddens, S. Oskarsson, J. K. Pickrell, K. Thom, P. Timshel, R. de Vlaming, A. Abdellaoui, T. S. Ahluwalia, J. Bacelis, C. Baumbach, G. Bjornsdottir, J. H. Brandsma, M. P. Concas, J. Derringer, N. A. Furlotte, T. E. Galesloot, G. Girotto, R. Gupta, L. M. Hall, S. E. Harris, E. Hofer, M. Horikoshi, J. E. Huffman, K. Kaasik, I. P. Kalafati, R. Karlsson, A. Kong, J. Lahti, S. J. van der Lee, C. de Leeuw, P. A. Lind, K. O. Lindgren, T. Liu, M. Mangino, J. Marten, E. Mihailov, M. B. Miller, P. J. van der Most, C. Oldmeadow, A. Payton, N. Pervjakova, W. J. Peyrot, Y. Qian, O. Raitakari, R. Rueedi, E. Salvi, B. Schmidt, K. E. Schraut, J. Shi, A. V. Smith, R. A. Poot, B. St Pourcain, A. Teumer, G. Thorleifsson, N. Verweij, D. Vuckovic, J. Wellmann, H. J. Westra, J. Yang, W. Zhao, Z. Zhu, B. Z. Alizadeh, N. Amin, A. Bakshi, S. E. Baumeister, G. Biino, K. Bønnelykke, P. A. Boyle, H. Campbell, F. P. Cappuccio, G. Davies, J. E. De Neve, P. Deloukas, I. Demuth, J. Ding, P. Eibich, L. Eisele, N. Eklund, D. M. Evans, J. D. Faul, M. F. Feitosa, A. J. Forstner, I. Gandin, B. Gunnarsson, B. V. Halldórsson, T. B. Harris, A. C. Heath, L. J. Hocking, E. G. Holliday, G. Homuth, M. A. Horan, J. J. Hottenga, P. L. de Jager, P. K. Joshi, A. Jugessur, M. A. Kaakinen, M. Kähönen, S. Kanoni, L. Keltigangas-Järvinen, L. A. Kiemeney, I. Kolcic, S. Koskinen, A. T. Kraja, M. Kroh, Z. Kutalik, A. Latvala, L. J. Launer, M. P. Lebreton, D. F. Levinson, P. Lichtenstein, P. Lichtner, D. C. Liewald, A. Loukola, P. A. Madden, R. Mägi, T. Mäki-Opas, R. E. Marioni, P. Marques-Vidal, G. A. Meddens, G. McMahon, C. Meisinger, T. Meitinger, Y. Milaneschi, L. Milani, G. W. Montgomery, R. Myhre, C. P. Nelson, D. R. Nyholt, W. E. Ollier, A. Palotie, L. Paternoster, N. L. Pedersen, K. E. Petrovic, D. J. Porteous, K. Räikkönen, S. M. Ring, A. Robino, O. Rostapshova, I. Rudan, A. Rustichini, V. Salomaa, A. R. Sanders, A. P. Sarin, H. Schmidt, R. J. Scott, B. H. Smith, J. A. Smith, J. A. Staessen, E. Steinhagen-Thiessen, K. Strauch, A. Terracciano, S. Ulivi, S. Vaccargiu, L. Quaye, F. J. van Rooij, C. Venturini, A. A. Vinkhuyzen, U. Völker, H. Völzke, J. M. Vonk, D. Vozzi, J. Waage, E. B. Ware, G. Willemsen, J. R. Attia, D. A. Bennett, K. Berger, L. Bertram, H. Bisgaard, D. I. Boomsma, I. B. Borecki, U. Bultmann, C. F. Chabris, Francesco Cucca, D. Cusi, I. J. Deary, G. V. Dedoussis, C. M. van Duijn, J. G. Eriksson, B. Franke, L. Franke, P. Gasparini, P. V. Gejman, C. Gieger, H. J. Grabe, J. Gratten, P. J. Groenen, V. Gudnason, P. van der Harst, C. Hayward, D. A. Hinds, W. Hoffmann, E. Hypponen, W. G. Iacono, B. Jacobsson, M. R. Järvelin, K. H. Jöckel, J. Kaprio, S. L. Kardia, T. Lehtimäki, S. F. Lehrer, P. K. Magnusson, N. G. Martin, M. McGue, A. Metspalu, N. Pendleton, B. W. Penninx, M. Perola, N. Pirastu, M. Pirastu, O. Polasek, D. Posthuma, C. Power, M. A. Province, N. J. Samani, D. Schlessinger, R. Schmidt, T. I. Sørensen, T. D. Spector, K. Stefansson, U. Thorsteinsdottir, A. R. Thurik, N. J. Timpson, H. Tiemeier, J. Y. Tung, A. G. Uitterlinden, V. Vitart, P. Vollenweider, D. R. Weir, J. F. Wilson, A. F. Wright, D. C. Conley, R. F. Krueger, G. D. Smith, A. Hofman, D. I. Laibson, S. E. Medland, M. N. Meyer, J. Yang, M. Johannesson, P. M. Visscher, T. Esko, P. D. Koellinger, D. Cesarini, D. J. Benjamin

    Research output: Contribution to journalArticle

    Abstract

    Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total n deaths = 79,702) and ∼2.4% lower risk for fathers (total n deaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

    Original languageEnglish (US)
    Pages (from-to)13366-13371
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume113
    Issue number47
    DOIs
    StatePublished - Nov 22 2016

    Keywords

    • Education
    • Genetics
    • Longevity
    • Polygenic score
    • Prediction

    ASJC Scopus subject areas

    • General

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  • Cite this

    Marioni, R. E., Ritchie, S. J., Joshi, P. K., Hagenaars, S. P., Okbay, A., Fischer, K., Adams, M. J., Hill, W. D., Davies, G., Nagy, R., Amador, C., Läll, K., Metspalu, A., Liewald, D. C., Campbell, A., Wilson, J. F., Hayward, C., Esko, T., Porteous, D. J., ... Benjamin, D. J. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences of the United States of America, 113(47), 13366-13371. https://doi.org/10.1073/pnas.1605334113