Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome

Emanuela Santini; Eric Klann

doi:10.1016/j.neuron.2016.03.023

Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome

Emanuela Santini, Eric Klann

Neural Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

Epilepsy in Angelman Syndrome is thought to originate from an imbalance between local excitatory-inhibitory circuits that results in a generalized hyperexcitability. In this issue of Neuron, Judson et al. (2016) demonstrate that selective maternal deletion of Ube3a in cortical GABAergic neurons causes circuit hyperexcitability, increased seizure severity, and EEG abnormalities.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Neuron
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/j.neuron.2016.03.023
State	Published - Apr 6 2016

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2016.03.023

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title = "Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome",

abstract = "Epilepsy in Angelman Syndrome is thought to originate from an imbalance between local excitatory-inhibitory circuits that results in a generalized hyperexcitability. In this issue of Neuron, Judson et al. (2016) demonstrate that selective maternal deletion of Ube3a in cortical GABAergic neurons causes circuit hyperexcitability, increased seizure severity, and EEG abnormalities.",

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Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome

Abstract

ASJC Scopus subject areas

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