Note 48 Concepts and tools in genetics and genomics 48 Introduction 48 Genes and chromosomes 49 Gene expression and protein synthesis - regulation of gene expression 49 DNA and human diversity 51 Complex, multifactorial disorders 53 Approaches used to conduct genetic studies 53 Expression analyses: RNA-based studies 57 Proteome analyses: protein-based studies 59 The new frontier: systems biology 60 Research-related issues unique to the study of pain alleles 60 Genetics and pain sensitivity 60 The complexities of determining genetic risk factors for chronic pain 60 Pharmacogenetics and analgesic drugs 61 Molecular biologic tools in the elucidation of pain mechanisms and drug discovery 63 References 63 The genetics of pain is a complex trait, due to a combination of genetic and environmental factors.
|Original language||English (US)|
|Title of host publication||Clinical Pain Management|
|Subtitle of host publication||Chronic Pain, Second Edition|
|Number of pages||17|
|State||Published - Jan 1 2008|
ASJC Scopus subject areas
- Health Professions(all)