TY - JOUR
T1 - Genome analysis linking recent European and African influenza (H5N1) viruses
AU - Salzberg, Steven L.
AU - Kingsford, Carl
AU - Cattoli, Giovanni
AU - Spiro, David J.
AU - Janies, Daniel A.
AU - Aly, Mona Mehrez
AU - Brown, Ian H.
AU - Couacy-Hymann, Emmanuel
AU - De Mia, Gian Mario
AU - Do, Huu Dung
AU - Guercio, Annalisa
AU - Joannis, Tony
AU - Ali, Ali Safar Maken
AU - Osmani, Azizullah
AU - Padalino, Iolanda
AU - Saad, Magdi D.
AU - Savić, Vladimir
AU - Sengamalay, Naomi A.
AU - Yingst, Samuel
AU - Zaborsky, Jennifer
AU - Zorman-Rojs, Olga
AU - Ghedin, Elodie
AU - Capua, Ilaria
PY - 2007/5
Y1 - 2007/5
N2 - To better understand the ecology and epidemiology of the highly pathogenic avian influenza virus in its transcontinental spread, we sequenced and analyzed the complete genomes of 36 recent influenza A (H5N1) viruses collected from birds in Europe, northern Africa, and southeastern Asia. These sequences, among the first complete genomes of influenza (H5N1) viruses outside Asia, clearly depict the lineages now infecting wild and domestic birds in Europe and Africa and show the relationships among these isolates and other strains affecting both birds and humans. The isolates fall into 3 distinct lineages, 1 of which contains all known non-Asian isolates. This new Euro-African lineage, which was the cause of several recent (2006) fatal human infections in Egypt and Iraq, has been introduced at least 3 times into the European-African region and has split into 3 distinct, independently evolving sublineages. One isolate provides evidence that 2 of these sublineages have recently reassorted.
AB - To better understand the ecology and epidemiology of the highly pathogenic avian influenza virus in its transcontinental spread, we sequenced and analyzed the complete genomes of 36 recent influenza A (H5N1) viruses collected from birds in Europe, northern Africa, and southeastern Asia. These sequences, among the first complete genomes of influenza (H5N1) viruses outside Asia, clearly depict the lineages now infecting wild and domestic birds in Europe and Africa and show the relationships among these isolates and other strains affecting both birds and humans. The isolates fall into 3 distinct lineages, 1 of which contains all known non-Asian isolates. This new Euro-African lineage, which was the cause of several recent (2006) fatal human infections in Egypt and Iraq, has been introduced at least 3 times into the European-African region and has split into 3 distinct, independently evolving sublineages. One isolate provides evidence that 2 of these sublineages have recently reassorted.
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U2 - 10.3201/eid1305.070013
DO - 10.3201/eid1305.070013
M3 - Article
C2 - 17553249
AN - SCOPUS:34248190910
SN - 1080-6040
VL - 13
SP - 713
EP - 718
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -