@article{0b329840e23442a0a90bbfb4f58f06ac,
title = "Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii",
abstract = "Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2, 212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5, 300 P. falciparum genes, more than 3, 300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.",
author = "Carlton, {Jane M.} and Angiuoli, {Samuel V.} and Suh, {Bernard B.} and Kooij, {Taco W.} and Mihaela Pertea and Silva, {Joana C.} and Ermolaeva, {Maria D.} and Allen, {Jonathan E.} and Selengut, {Jeremy D.} and Koo, {Hean L.} and Peterson, {Jeremy D.} and Mihai Pop and Kosack, {Daniel S.} and Shumway, {Martin F.} and Bidwell, {Shelby L.} and Shallom, {Shamira J.} and {Van Aken}, {Susan E.} and Riedmuller, {Steven B.} and Feldblyum, {Tamara V.} and Cho, {Jennifer K.} and John Quackenbush and Martha Sedegah and Azadeh Shoaibi and Cummings, {Leda M.} and Laurence Florens and Yates, {John R.} and Raine, {J. Dale} and Sinden, {Robert E.} and Harris, {Michael A.} and Cunningham, {Deirdre A.} and Preiser, {Peter R.} and Bergman, {Lawrence W.} and Vaidya, {Akhil B.} and {Van Lin}, {Leo H.} and Janse, {Chris J.} and Waters, {Andrew P.} and Smith, {Hamilton O.} and White, {Owen R.} and Salzberg, {Steven L.} and Venter, {J. Craig} and Fraser, {Claire M.} and Hoffman, {Stephen L.} and Gardner, {Malcolm J.} and Carucci, {Daniel J.}",
note = "Funding Information: We thank S. Cawley and T. Pace for collaborative work; J. Mendoza and J. Ramesar for technical support; C. Long for the gift of a P. y. yoelii cDNA library; R. Arcilla and W. Weiss for parasite material; and J. Eisen and S. Sullivan for critical reading of the manuscript. L.H.v.L. was supported by an INCO-DEV programme grant from the European Community; T.W.K. was supported by a Rijks Universiteit te Leiden studentship; J.D.R. was supported with funds from the Wellcome Trust. This project was funded by the US Department of Defense through cooperative agreement with the US Army Medical Research and Material Command and by the Naval Medical Research Center. The opinions expressed are those of the authors and do not reflect the official policy of the Department of the Navy, Department of Defense, or the US government.",
year = "2002",
month = oct,
day = "3",
doi = "10.1038/nature01099",
language = "English (US)",
volume = "419",
pages = "512--519",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "6906",
}