Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Jessica N.Cooke Bailey, Stephanie J. Loomis, Jae H. Kang, R. Rand Allingham, Puya Gharahkhani, Chiea Chuen Khor, Kathryn P. Burdon, Hugues Aschard, Daniel I. Chasman, Robert P. Igo, Pirro G. Hysi, Craig A. Glastonbury, Allison Ashley-Koch, Murray Brilliant, Andrew A. Brown, Donald L. Budenz, Alfonso Buil, Ching Yu Cheng, Hyon Choi, William G. ChristenGary Curhan, Immaculata De Vivo, John H. Fingert, Paul J. Foster, Charles Fuchs, Douglas Gaasterland, Terry Gaasterland, Alex W. Hewitt, Frank Hu, David J. Hunter, Anthony P. Khawaja, Richard K. Lee, Zheng Li, Paul R. Lichter, David A. Mackey, Peter McGuffin, Paul Mitchell, Sayoko E. Moroi, Shamira A. Perera, Keating W. Pepper, Qibin Qi, Tony Realini, Julia E. Richards, Paul M. Ridker, Eric Rimm, Robert Ritch, Marylyn Ritchie, Joel S. Schuman, William K. Scott, Kuldev Singh, Arthur J. Sit, Yeunjoo E. Song, Rulla M. Tamimi, Fotis Topouzis, Ananth C. Viswanathan, Shefali Setia Verma, Douglas Vollrath, Jie Jin Wang, Nicole Weisschuh, Bernd Wissinger, Gadi Wollstein, Tien Y. Wong, Brian L. Yaspan, Donald J. Zack, Kang Zhang, Robert N. Weinreb, Margaret A. Pericak-Vance, Kerrin Small, Christopher J. Hammond, Tin Aung, Yutao Liu, Eranga N. Vithana, Stuart MacGregor, Jamie E. Craig, Peter Kraft, Gareth Howell, Michael A. Hauser, Louis R. Pasquale, Jonathan L. Haines, Janey L. Wiggs

    Research output: Contribution to journalArticle

    Abstract

    Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. To identify new susceptibility loci, we performed meta-analysis on genome-wide association study (GWAS) results from eight independent studies from the United States (3,853 cases and 33,480 controls) and investigated the most significantly associated SNPs in two Australian studies (1,252 cases and 2,592 controls), three European studies (875 cases and 4,107 controls) and a Singaporean Chinese study (1,037 cases and 2,543 controls). A meta-analysis of the top SNPs identified three new associated loci: rs35934224[T] in TXNRD2 (odds ratio (OR) = 0.78, P = 4.05 × 10 -11) encoding a mitochondrial protein required for redox homeostasis; rs7137828[T] in ATXN2 (OR = 1.17, P = 8.73 × 10 -10); and rs2745572[A] upstream of FOXC1 (OR = 1.17, P = 1.76 × 10 -10). Using RT-PCR and immunohistochemistry, we show TXNRD2 and ATXN2 expression in retinal ganglion cells and the optic nerve head. These results identify new pathways underlying POAG susceptibility and suggest new targets for preventative therapies.

    Original languageEnglish (US)
    Pages (from-to)189-194
    Number of pages6
    JournalNature Genetics
    Volume48
    Issue number2
    DOIs
    StatePublished - Feb 1 2016

    ASJC Scopus subject areas

    • Genetics

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  • Cite this

    Bailey, J. N. C., Loomis, S. J., Kang, J. H., Allingham, R. R., Gharahkhani, P., Khor, C. C., Burdon, K. P., Aschard, H., Chasman, D. I., Igo, R. P., Hysi, P. G., Glastonbury, C. A., Ashley-Koch, A., Brilliant, M., Brown, A. A., Budenz, D. L., Buil, A., Cheng, C. Y., Choi, H., ... Wiggs, J. L. (2016). Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nature Genetics, 48(2), 189-194. https://doi.org/10.1038/ng.3482