Genome-wide association study of Arabidopsis thaliana leaf microbial community

Matthew W. Horton; Natacha Bodenhausen; Kathleen Beilsmith; Dazhe Meng; Brian D. Muegge; Sathish Subramanian; M. Madlen Vetter; Bjarni J. Vilhjálmsson; Magnus Nordborg; Jeffrey I. Gordon; Joy Bergelson

doi:10.1038/ncomms6320

Genome-wide association study of Arabidopsis thaliana leaf microbial community

Matthew W. Horton, Natacha Bodenhausen, Kathleen Beilsmith, Dazhe Meng, Brian D. Muegge, Sathish Subramanian, M. Madlen Vetter, Bjarni J. Vilhjálmsson, Magnus Nordborg, Jeffrey I. Gordon, Joy Bergelson

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.

Original language	English (US)
Article number	5320
Journal	Nature communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms6320
State	Published - 2014

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/ncomms6320

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abstract = "Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.",

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AU - Horton, Matthew W.

AU - Bodenhausen, Natacha

AU - Beilsmith, Kathleen

AU - Meng, Dazhe

AU - Muegge, Brian D.

AU - Subramanian, Sathish

AU - Vetter, M. Madlen

AU - Vilhjálmsson, Bjarni J.

AU - Nordborg, Magnus

AU - Gordon, Jeffrey I.

AU - Bergelson, Joy

PY - 2014

Y1 - 2014

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AB - Identifying the factors that influence the outcome of host-microbial interactions is critical to protecting biodiversity, minimizing agricultural losses and improving human health. A few genes that determine symbiosis or resistance to infectious disease have been identified in model species, but a comprehensive examination of how a host genotype influences the structure of its microbial community is lacking. Here we report the results of a field experiment with the model plant Arabidopsis thaliana to identify the fungi and bacteria that colonize its leaves and the host loci that influence the microbe numbers. The composition of this community differs among accessions of A. thaliana. Genome-wide association studies (GWAS) suggest that plant loci responsible for defense and cell wall integrity affect variation in this community. Furthermore, species richness in the bacterial community is shaped by host genetic variation, notably at loci that also influence the reproduction of viruses, trichome branching and morphogenesis.

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Genome-wide association study of Arabidopsis thaliana leaf microbial community

Abstract

ASJC Scopus subject areas

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