Genomic and proteomic approaches for Chagas' disease: Critical analysis of diagnostic methods

Jorge A. Huete-Pérez, Rafael Ernesto Flores-Obando, Elodie Ghedin, Conor R. Caffrey

Research output: Contribution to journalReview articlepeer-review

Abstract

Trypanosoma cruzi is the etiologic agent of Chagas' disease, a chronic inflammatory condition that results in heart and digestive complications. The first draft of the parasite genome is now complete and it is expected that, along with the published genomic and proteomic analyses discussed herein, it will lead to the identification of crucial genes and proteins directly associated with disease. This article reviews the current research trends addressing host-parasite interaction, parasite genetic variability and diagnosis. These advances will certainly bring about major developments not only in our understanding of Trypanosoma cruzi biology, but also in the application of new technologies to disease prevention and control.

Original languageEnglish (US)
Pages (from-to)521-530
Number of pages10
JournalExpert Review of Molecular Diagnostics
Volume5
Issue number4
DOIs
StatePublished - Jul 2005

Keywords

  • Chagas' disease
  • Diagnosis
  • Genomics
  • Microarray
  • Proteomics
  • Transcriptomics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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