Genomic and proteomic approaches for Chagas' disease: Critical analysis of diagnostic methods

Jorge A. Huete-Pérez; Rafael Ernesto Flores-Obando; Elodie Ghedin; Conor R. Caffrey

doi:10.1586/14737159.5.4.521

Genomic and proteomic approaches for Chagas' disease: Critical analysis of diagnostic methods

Jorge A. Huete-Pérez, Rafael Ernesto Flores-Obando, Elodie Ghedin, Conor R. Caffrey

Research output: Contribution to journal › Review article › peer-review

Abstract

Trypanosoma cruzi is the etiologic agent of Chagas' disease, a chronic inflammatory condition that results in heart and digestive complications. The first draft of the parasite genome is now complete and it is expected that, along with the published genomic and proteomic analyses discussed herein, it will lead to the identification of crucial genes and proteins directly associated with disease. This article reviews the current research trends addressing host-parasite interaction, parasite genetic variability and diagnosis. These advances will certainly bring about major developments not only in our understanding of Trypanosoma cruzi biology, but also in the application of new technologies to disease prevention and control.

Original language	English (US)
Pages (from-to)	521-530
Number of pages	10
Journal	Expert Review of Molecular Diagnostics
Volume	5
Issue number	4
DOIs	https://doi.org/10.1586/14737159.5.4.521
State	Published - Jul 2005

Keywords

Chagas' disease
Diagnosis
Genomics
Microarray
Proteomics
Transcriptomics

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Medicine
Molecular Biology
Genetics

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10.1586/14737159.5.4.521

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abstract = "Trypanosoma cruzi is the etiologic agent of Chagas' disease, a chronic inflammatory condition that results in heart and digestive complications. The first draft of the parasite genome is now complete and it is expected that, along with the published genomic and proteomic analyses discussed herein, it will lead to the identification of crucial genes and proteins directly associated with disease. This article reviews the current research trends addressing host-parasite interaction, parasite genetic variability and diagnosis. These advances will certainly bring about major developments not only in our understanding of Trypanosoma cruzi biology, but also in the application of new technologies to disease prevention and control.",

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AU - Ghedin, Elodie

AU - Caffrey, Conor R.

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KW - Microarray

KW - Proteomics

KW - Transcriptomics

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Genomic and proteomic approaches for Chagas' disease: Critical analysis of diagnostic methods

Abstract

Keywords

ASJC Scopus subject areas

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