Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies

Elliott H. Sherr; R. Owen; D. G. Albertson; D. Pinkel; P. D. Cotter; A. M. Slavotinek; S. W. Hetts; R. J. Jeremy; G. Schilmoeller; K. Schilmoeller; M. Wakahiro; A. J. Barkovich

doi:10.1212/01.wnl.0000183066.09239.b6

Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies

Elliott H. Sherr, R. Owen, D. G. Albertson, D. Pinkel, P. D. Cotter, A. M. Slavotinek, S. W. Hetts, R. J. Jeremy, G. Schilmoeller, K. Schilmoeller, M. Wakahiro, A. J. Barkovich

Oral and Maxillofacial Surgery

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Abstract

Absence of the corpus callosum is often associated with cognitive deficits, autism, and epilepsy. Using a genomic microarray, the authors analyzed DNA from 25 patients with radiographically confirmed callosal anomalies and identified three patients with de novo copy number changes in chromosome regions 2q37, 6qter, and 8p. Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations.

Original language	English (US)
Pages (from-to)	1496-1498
Number of pages	3
Journal	Neurology
Volume	65
Issue number	9
DOIs	https://doi.org/10.1212/01.wnl.0000183066.09239.b6
State	Published - Nov 8 2005

ASJC Scopus subject areas

Clinical Neurology

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Sherr, E. H., Owen, R., Albertson, D. G., Pinkel, D., Cotter, P. D., Slavotinek, A. M., Hetts, S. W., Jeremy, R. J., Schilmoeller, G., Schilmoeller, K., Wakahiro, M., & Barkovich, A. J. (2005). Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies. Neurology, 65(9), 1496-1498. https://doi.org/10.1212/01.wnl.0000183066.09239.b6

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AU - Owen, R.

AU - Albertson, D. G.

AU - Pinkel, D.

AU - Cotter, P. D.

AU - Slavotinek, A. M.

AU - Hetts, S. W.

AU - Jeremy, R. J.

AU - Schilmoeller, G.

AU - Schilmoeller, K.

AU - Wakahiro, M.

AU - Barkovich, A. J.

PY - 2005/11/8

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AB - Absence of the corpus callosum is often associated with cognitive deficits, autism, and epilepsy. Using a genomic microarray, the authors analyzed DNA from 25 patients with radiographically confirmed callosal anomalies and identified three patients with de novo copy number changes in chromosome regions 2q37, 6qter, and 8p. Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations.

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Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies

Abstract

ASJC Scopus subject areas

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