Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies

Elliott H. Sherr, R. Owen, D. G. Albertson, D. Pinkel, P. D. Cotter, A. M. Slavotinek, S. W. Hetts, R. J. Jeremy, G. Schilmoeller, K. Schilmoeller, M. Wakahiro, A. J. Barkovich

Research output: Contribution to journalArticle

Abstract

Absence of the corpus callosum is often associated with cognitive deficits, autism, and epilepsy. Using a genomic microarray, the authors analyzed DNA from 25 patients with radiographically confirmed callosal anomalies and identified three patients with de novo copy number changes in chromosome regions 2q37, 6qter, and 8p. Chromosomal deletions and duplications may be a relatively common cause of cerebral malformations.

Original languageEnglish (US)
Pages (from-to)1496-1498
Number of pages3
JournalNeurology
Volume65
Issue number9
DOIs
StatePublished - Nov 8 2005

ASJC Scopus subject areas

  • Clinical Neurology

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    Sherr, E. H., Owen, R., Albertson, D. G., Pinkel, D., Cotter, P. D., Slavotinek, A. M., Hetts, S. W., Jeremy, R. J., Schilmoeller, G., Schilmoeller, K., Wakahiro, M., & Barkovich, A. J. (2005). Genomic microarray analysis identifies candidate loci in patients with corpus callosum anomalies. Neurology, 65(9), 1496-1498. https://doi.org/10.1212/01.wnl.0000183066.09239.b6