Genomic microarrays in human genetic disease and cancer

Donna G. Albertson; Daniel Pinkel

doi:10.1093/hmg/ddg261

Genomic microarrays in human genetic disease and cancer

Donna G. Albertson, Daniel Pinkel

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Alterations in the genome that lead to changes in DNA sequence copy number are a characteristic of solid tumors and are found in association with developmental abnormalities and/or mental retardation. Comparative genomic hybridization (CGH) can be used to detect and map these changes. Recent improvements in the resolution and sensitivity of CGH have been possible through implementation of microarray-based CGH (array CGH). Here we discuss the performance characteristics of different array platforms and review some of the recent applications of array CGH in cancer and medical genetics.

Original language	English (US)
Pages (from-to)	R145-R152
Journal	Human Molecular Genetics
Volume	12
Issue number	REV. ISS. 2
DOIs	https://doi.org/10.1093/hmg/ddg261
State	Published - Oct 15 2003

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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Genomic microarrays in human genetic disease and cancer

Abstract

ASJC Scopus subject areas

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