TY - JOUR
T1 - Genomics of reproductive traits and cardiometabolic disease risk in African American Women
AU - Hardy, Theresa M.
AU - De Mendoza, Veronica Barcelona
AU - Sun, Yan V.
AU - Taylor, Jacquelyn Y.
N1 - Funding Information:
Accepted for publication November 16, 2018. This work was supported by Grant R01Nr013520 from the National Institute of Nursing Research of the U.S. National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. As an integrative review of the literature, this study was exempt from institutional review board approval. The authors have no conflicts of interest to report. Corresponding author: Theresa Hardy, PhD, RN, New York University Rory Meyers College of Nursing, 433 First Avenue, 7th Floor, New York, NY 10010 (e-mail: th89@nyu.edu).
Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background Age at menarche and age at natural menopause occur significantly earlier in African American women than in other ethnic groups. African American women also have twice the prevalence of cardiometabolic disorders related to the timing of these reproductive traits. Objectives The objectives of this integrative review were to (a) summarize the genome-wide association studies of reproductive traits in African American women, (b) identify genes that overlap with reproductive traits and cardiometabolic risk factors in African American women, and (c) propose biological mechanisms explaining the link between reproductive traits and cardiometabolic risk factors. Methods PubMed was searched for genome-wide association studies of genes associated with reproductive traits in African American women. After extracting and summarizing the primary genes, we examined whether any of the associations with reproductive traits had also been identified with cardiometabolic risk factors in African American women. Results Seven studies met the inclusion criteria. Associations with both reproductive and cardiometabolic traits were reported in or near the following genes: FTO, SEC16B, TMEM18, APOE, PHACTR1, KCNQ1, LDLR, PIK3R1, and RORA. Biological pathways implicated include body weight regulation, vascular homeostasis, and lipid metabolism. Discussion A better understanding of the genetic basis of reproductive traits in African American women may provide insight into the biological mechanisms linking variation in these traits with increased risk for cardiometabolic disorders in this population.
AB - Background Age at menarche and age at natural menopause occur significantly earlier in African American women than in other ethnic groups. African American women also have twice the prevalence of cardiometabolic disorders related to the timing of these reproductive traits. Objectives The objectives of this integrative review were to (a) summarize the genome-wide association studies of reproductive traits in African American women, (b) identify genes that overlap with reproductive traits and cardiometabolic risk factors in African American women, and (c) propose biological mechanisms explaining the link between reproductive traits and cardiometabolic risk factors. Methods PubMed was searched for genome-wide association studies of genes associated with reproductive traits in African American women. After extracting and summarizing the primary genes, we examined whether any of the associations with reproductive traits had also been identified with cardiometabolic risk factors in African American women. Results Seven studies met the inclusion criteria. Associations with both reproductive and cardiometabolic traits were reported in or near the following genes: FTO, SEC16B, TMEM18, APOE, PHACTR1, KCNQ1, LDLR, PIK3R1, and RORA. Biological pathways implicated include body weight regulation, vascular homeostasis, and lipid metabolism. Discussion A better understanding of the genetic basis of reproductive traits in African American women may provide insight into the biological mechanisms linking variation in these traits with increased risk for cardiometabolic disorders in this population.
KW - African American
KW - genomics
KW - reproductive
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U2 - 10.1097/NNR.0000000000000337
DO - 10.1097/NNR.0000000000000337
M3 - Article
C2 - 30570522
AN - SCOPUS:85062420565
VL - 68
SP - 135
EP - 144
JO - Nursing Research
JF - Nursing Research
SN - 0029-6562
IS - 2
ER -