TY - GEN
T1 - Genomics via Optical Mapping III
T2 - 7th International Conference on Intelligent Systems for Molecular Biology, ISMB 1999
AU - Anantharaman, Thomas
AU - Mishra, Bud
AU - Schwartz, David
N1 - Funding Information:
The research presented here was partly supported by an NSF Cm’eer grant: IRI-9702071, an NItI Grant: NItI R01 HG0025-07 and a grant from the Chiton Corporation.
Publisher Copyright:
Copyright © 1999, American Association for Artificial Intelligence (www.aaai.org). All rights reserved.
PY - 1999
Y1 - 1999
N2 - In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set. of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1 4Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scalable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data.
AB - In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set. of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1 4Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scalable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data.
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M3 - Conference contribution
C2 - 10786282
AN - SCOPUS:0033288774
T3 - Proceedings of the 7th International Conference on Intelligent Systems for Molecular Biology, ISMB 1999
SP - 18
EP - 27
BT - Proceedings of the 7th International Conference on Intelligent Systems for Molecular Biology, ISMB 1999
PB - AAAI press
Y2 - 6 August 1999 through 10 August 1999
ER -