Getting trichy: Tools and approaches to interrogating Trichomonas vaginalis in a post-genome world

Melissa D. Conrad; Martina Bradic; Sally D. Warring; Andrew W. Gorman; Jane M. Carlton

doi:10.1016/j.pt.2012.10.004

Getting trichy: Tools and approaches to interrogating Trichomonas vaginalis in a post-genome world

Melissa D. Conrad, Martina Bradic, Sally D. Warring, Andrew W. Gorman, Jane M. Carlton

Research output: Contribution to journal › Review article › peer-review

Abstract

Trichomonas vaginalis is a parasite of the urogenital tract in men and women, with a worldwide presence and significant implications for global public health. T. vaginalis research entered the age of genomics with the publication of the first genome sequence in 2007, but subsequent utilization of other 'omics' technologies and methods has been slow. Here, we review some of the tools and approaches available to interrogate T. vaginalis biology, with an emphasis on recent advances and current limitations, and draw attention to areas where further efforts are needed to examine effectively the complex and intriguing biology of the parasite.

Original language	English (US)
Pages (from-to)	17-25
Number of pages	9
Journal	Trends in Parasitology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.pt.2012.10.004
State	Published - Jan 2013

Keywords

Evolution.
Molecular tools
Omics
Population genetics
Trichomonas vaginalis

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/j.pt.2012.10.004

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title = "Getting trichy: Tools and approaches to interrogating Trichomonas vaginalis in a post-genome world",

abstract = "Trichomonas vaginalis is a parasite of the urogenital tract in men and women, with a worldwide presence and significant implications for global public health. T. vaginalis research entered the age of genomics with the publication of the first genome sequence in 2007, but subsequent utilization of other 'omics' technologies and methods has been slow. Here, we review some of the tools and approaches available to interrogate T. vaginalis biology, with an emphasis on recent advances and current limitations, and draw attention to areas where further efforts are needed to examine effectively the complex and intriguing biology of the parasite.",

keywords = "Evolution., Molecular tools, Omics, Population genetics, Trichomonas vaginalis",

author = "Conrad, {Melissa D.} and Martina Bradic and Warring, {Sally D.} and Gorman, {Andrew W.} and Carlton, {Jane M.}",

note = "Funding Information: This work was funded in part by US National Institutes of Health (NIH) grant 5R21AI083954-02. M.D.C. and A.G. were partially supported by NIH training grant 5T32AI007180-28, and S.D.W. by the MacCracken Program in the Graduate School of Arts and Science at New York University. We thank Steven Sullivan for his comments and proof-reading, and apologize to authors whose work could not be cited due to space constraints.",

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doi = "10.1016/j.pt.2012.10.004",

language = "English (US)",

volume = "29",

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journal = "Trends in Parasitology",

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AU - Conrad, Melissa D.

AU - Bradic, Martina

AU - Warring, Sally D.

AU - Gorman, Andrew W.

AU - Carlton, Jane M.

N1 - Funding Information: This work was funded in part by US National Institutes of Health (NIH) grant 5R21AI083954-02. M.D.C. and A.G. were partially supported by NIH training grant 5T32AI007180-28, and S.D.W. by the MacCracken Program in the Graduate School of Arts and Science at New York University. We thank Steven Sullivan for his comments and proof-reading, and apologize to authors whose work could not be cited due to space constraints.

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N2 - Trichomonas vaginalis is a parasite of the urogenital tract in men and women, with a worldwide presence and significant implications for global public health. T. vaginalis research entered the age of genomics with the publication of the first genome sequence in 2007, but subsequent utilization of other 'omics' technologies and methods has been slow. Here, we review some of the tools and approaches available to interrogate T. vaginalis biology, with an emphasis on recent advances and current limitations, and draw attention to areas where further efforts are needed to examine effectively the complex and intriguing biology of the parasite.

AB - Trichomonas vaginalis is a parasite of the urogenital tract in men and women, with a worldwide presence and significant implications for global public health. T. vaginalis research entered the age of genomics with the publication of the first genome sequence in 2007, but subsequent utilization of other 'omics' technologies and methods has been slow. Here, we review some of the tools and approaches available to interrogate T. vaginalis biology, with an emphasis on recent advances and current limitations, and draw attention to areas where further efforts are needed to examine effectively the complex and intriguing biology of the parasite.

KW - Evolution.

KW - Molecular tools

KW - Omics

KW - Population genetics

KW - Trichomonas vaginalis

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Getting trichy: Tools and approaches to interrogating Trichomonas vaginalis in a post-genome world

Abstract

Keywords

ASJC Scopus subject areas

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