TY - JOUR
T1 - Glia and orofacial pain
T2 - Progress and future directions
AU - Ye, Yi
AU - Salvo, Elizabeth
AU - Romero-Reyes, Marcela
AU - Akerman, Simon
AU - Shimizu, Emi
AU - Kobayashi, Yoshifumi
AU - Michot, Benoit
AU - Gibbs, Jennifer
N1 - Funding Information:
This work is supported by NIH grants R03DE027777 (Y. Ye), R01DE029493 (Y. Ye) and R01DE025885 (E. Shimizu).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/5/2
Y1 - 2021/5/2
N2 - Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions.
AB - Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions.
KW - Astrocytes
KW - Dental pulp injury
KW - Head and neck cancer
KW - Headache
KW - Microglia
KW - Satellite ganglia cells
KW - Schwann cell
KW - Toothache
KW - Trigeminal ganglia
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U2 - 10.3390/ijms22105345
DO - 10.3390/ijms22105345
M3 - Review article
C2 - 34069553
AN - SCOPUS:85106003606
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 10
M1 - 5345
ER -