Gliotoxin: Nature's way of making the epidithio bridge

Tynchtyk Amatov, Ullrich Jahn

Research output: Contribution to journalArticlepeer-review

Abstract

GliTzy biosynthesis! A detailed picture of the key transformations during the biogenesis of gliotoxin has recently been created. Almost every intermediate in the biosynthetic pathway and the pertinent enzymatic machinery was isolated and fully characterized, thus placing the unique incorporation of the sulfur atoms as well as the formation of the epidithio bridge catalyzed by the key enzyme GliT and its consequences into the limelight.

Original languageEnglish (US)
Pages (from-to)3312-3314
Number of pages3
JournalAngewandte Chemie - International Edition
Volume53
Issue number13
DOIs
StatePublished - Mar 24 2014

Keywords

  • biosynthesis
  • bridged alkaloids
  • disulfide
  • epipolythiodioxopiperazine
  • gliotoxin

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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