TY - JOUR
T1 - Global, regional, and national burden of congenital heart disease, 1990–2017
T2 - a systematic analysis for the Global Burden of Disease Study 2017
AU - Zimmerman, Meghan S.
AU - Smith, Alison Grace Carswell
AU - Sable, Craig A.
AU - Echko, Michelle Marie
AU - Wilner, Lauren B.
AU - Olsen, Helen Elizabeth
AU - Atalay, Hagos Tasew
AU - Awasthi, Ashish
AU - Bhutta, Zulfiqar A.
AU - Boucher, Jackie Lee Anne
AU - Castro, Franz
AU - Cortesi, Paolo Angelo
AU - Dubey, Manisha
AU - Fischer, Florian
AU - Hamidi, Samer
AU - Hay, Simon I.
AU - Hoang, Chi Linh
AU - Hugo-Hamman, Christopher
AU - Jenkins, Kathy J.
AU - Kar, Anita
AU - Khalil, Ibrahim A.
AU - Kumar, Raman Krishna
AU - Kwan, Gene F.
AU - Mengistu, Desalegn Tadese
AU - Mokdad, Ali H.
AU - Naghavi, Mohsen
AU - Negesa, Lemma
AU - Negoi, Ionut
AU - Negoi, Ruxandra Irina
AU - Nguyen, Cuong Tat
AU - Nguyen, Huong Lan Thi
AU - Nguyen, Long Hoang
AU - Nguyen, Son Hoang
AU - Nguyen, Trang Huyen
AU - Nixon, Molly R.
AU - Noubiap, Jean Jacques
AU - Patel, Shanti
AU - Peprah, Emmanuel K.
AU - Reiner, Robert C.
AU - Roth, Gregory A.
AU - Temsah, Mohamad Hani
AU - Tovani-Palone, Marcos Roberto
AU - Towbin, Jeffrey A.
AU - Tran, Bach Xuan
AU - Tran, Tung Thanh
AU - Truong, Nu Thi
AU - Vos, Theo
AU - Vosoughi, Kia
AU - Weintraub, Robert G.
AU - Weldegwergs, Kidu Gidey
AU - Zaidi, Zoubida
AU - Zheleva, Bistra
AU - Zuhlke, Liesl
AU - Murray, Christopher J.L.
AU - Martin, Gerard R.
AU - Kassebaum, Nicholas J.
N1 - Publisher Copyright:
© 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
PY - 2020/3
Y1 - 2020/3
N2 - Background: Previous congenital heart disease estimates came from few data sources, were geographically narrow, and did not evaluate congenital heart disease throughout the life course. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, this study aimed to provide comprehensive estimates of congenital heart disease mortality, prevalence, and disability by age for 195 countries and territories from 1990 to 2017. Methods: Mortality estimates were generated for aggregate congenital heart disease and non-fatal estimates for five subcategories (single ventricle and single ventricle pathway congenital heart anomalies; severe congenital heart anomalies excluding single ventricle heart defects; critical malformations of great vessels, congenital valvular heart disease, and patent ductus arteriosus; ventricular septal defect and atrial septal defect; and other congenital heart anomalies), for 1990 through to 2017. All available global data were systematically analysed to generate congenital heart disease mortality estimates (using Cause of Death Ensemble modelling) and prevalence estimates (DisMod-MR 2·1). Systematic literature reviews of all types of congenital anomalies to capture information on prevalence, associated mortality, and long-term health outcomes on congenital heart disease informed subsequent disability estimates. Findings: Congenital heart disease caused 261 247 deaths (95% uncertainty interval 216 567–308 159) globally in 2017, a 34·5% decline from 1990, with 180 624 deaths (146 825–214 178) being among infants (aged <1 years). Congenital heart disease mortality rates declined with increasing Socio-demographic Index (SDI); most deaths occurred in countries in the low and low-middle SDI quintiles. The prevalence rates of congenital heart disease at birth changed little temporally or by SDI, resulting in 11 998 283 (10 958 658–13 123 888) people living with congenital heart disease globally, an 18·7% increase from 1990 to 2017, and causing a total of 589 479 (287 200–973 359) years lived with disability. Interpretation: Congenital heart disease is a large, rapidly emerging global problem in child health. Without the ability to substantially alter the prevalence of congenital heart disease, interventions and resources must be used to improve survival and quality of life. Our findings highlight the large global inequities in congenital heart disease and can serve as a starting point for policy changes to improve screening, treatment, and data collection. Funding: Bill & Melinda Gates Foundation.
AB - Background: Previous congenital heart disease estimates came from few data sources, were geographically narrow, and did not evaluate congenital heart disease throughout the life course. Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, this study aimed to provide comprehensive estimates of congenital heart disease mortality, prevalence, and disability by age for 195 countries and territories from 1990 to 2017. Methods: Mortality estimates were generated for aggregate congenital heart disease and non-fatal estimates for five subcategories (single ventricle and single ventricle pathway congenital heart anomalies; severe congenital heart anomalies excluding single ventricle heart defects; critical malformations of great vessels, congenital valvular heart disease, and patent ductus arteriosus; ventricular septal defect and atrial septal defect; and other congenital heart anomalies), for 1990 through to 2017. All available global data were systematically analysed to generate congenital heart disease mortality estimates (using Cause of Death Ensemble modelling) and prevalence estimates (DisMod-MR 2·1). Systematic literature reviews of all types of congenital anomalies to capture information on prevalence, associated mortality, and long-term health outcomes on congenital heart disease informed subsequent disability estimates. Findings: Congenital heart disease caused 261 247 deaths (95% uncertainty interval 216 567–308 159) globally in 2017, a 34·5% decline from 1990, with 180 624 deaths (146 825–214 178) being among infants (aged <1 years). Congenital heart disease mortality rates declined with increasing Socio-demographic Index (SDI); most deaths occurred in countries in the low and low-middle SDI quintiles. The prevalence rates of congenital heart disease at birth changed little temporally or by SDI, resulting in 11 998 283 (10 958 658–13 123 888) people living with congenital heart disease globally, an 18·7% increase from 1990 to 2017, and causing a total of 589 479 (287 200–973 359) years lived with disability. Interpretation: Congenital heart disease is a large, rapidly emerging global problem in child health. Without the ability to substantially alter the prevalence of congenital heart disease, interventions and resources must be used to improve survival and quality of life. Our findings highlight the large global inequities in congenital heart disease and can serve as a starting point for policy changes to improve screening, treatment, and data collection. Funding: Bill & Melinda Gates Foundation.
KW - Adolescent
KW - Child
KW - Child, Preschool
KW - Disabled Persons/statistics & numerical data
KW - Global Burden of Disease
KW - Global Health
KW - Heart Defects, Congenital/classification
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Prevalence
KW - Systematic Reviews as Topic
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U2 - 10.1016/S2352-4642(19)30402-X
DO - 10.1016/S2352-4642(19)30402-X
M3 - Article
C2 - 31978374
AN - SCOPUS:85079540364
SN - 2352-4642
VL - 4
SP - 185
EP - 200
JO - The Lancet Child and Adolescent Health
JF - The Lancet Child and Adolescent Health
IS - 3
ER -