Global signatures of protein and mRNA expression levels

Raquel De Sousa Abreu; Luiz O. Penalva; Edward M. Marcotte; Christine Vogel

doi:10.1039/b908315d

Global signatures of protein and mRNA expression levels

Raquel De Sousa Abreu, Luiz O. Penalva, Edward M. Marcotte, Christine Vogel

Biology and Genomics

Research output: Contribution to journal › Review article › peer-review

Abstract

Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

Original language	English (US)
Pages (from-to)	1512-1526
Number of pages	15
Journal	Molecular BioSystems
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/b908315d
State	Published - 2009

ASJC Scopus subject areas

Biotechnology
Molecular Biology

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title = "Global signatures of protein and mRNA expression levels",

abstract = "Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.",

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year = "2009",

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AU - Penalva, Luiz O.

AU - Marcotte, Edward M.

AU - Vogel, Christine

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AB - Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

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Global signatures of protein and mRNA expression levels

Abstract

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