Glucose-oxidase based self-destructing polymeric vesicles

Alessandro Napoli; Mark J. Boerakker; Nicola Tirelli; Roeland J.M. Nolte; Nico A.J.M. Sommerdijk; Jeffrey A. Hubbell

doi:10.1021/la0357054

Glucose-oxidase based self-destructing polymeric vesicles

Alessandro Napoli, Mark J. Boerakker, Nicola Tirelli, Roeland J.M. Nolte, Nico A.J.M. Sommerdijk, Jeffrey A. Hubbell

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidatiye environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.

Original language	English (US)
Pages (from-to)	3487-3491
Number of pages	5
Journal	Langmuir
Volume	20
Issue number	9
DOIs	https://doi.org/10.1021/la0357054
State	Published - Apr 27 2004

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la0357054

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title = "Glucose-oxidase based self-destructing polymeric vesicles",

abstract = "We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ({"}polymersomes{"}) of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidatiye environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.",

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T1 - Glucose-oxidase based self-destructing polymeric vesicles

AU - Napoli, Alessandro

AU - Boerakker, Mark J.

AU - Tirelli, Nicola

AU - Nolte, Roeland J.M.

AU - Sommerdijk, Nico A.J.M.

AU - Hubbell, Jeffrey A.

PY - 2004/4/27

Y1 - 2004/4/27

N2 - We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidatiye environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.

AB - We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidatiye environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.

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Glucose-oxidase based self-destructing polymeric vesicles

Abstract

ASJC Scopus subject areas

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