Glycine mediated alterations in intracellular pH

Joshua S. Green, Vibhakar C. Kotak, Dan H. Sanes

Research output: Contribution to journalArticlepeer-review


Glycinergic transmission shapes the coding properties of the lateral superior olivary nucleus (LSO). We investigated intracellular pH responses in the LSO to glycine using BCECF-AM in brain slices. With extracellular bicarbonate, glycine produced an alkalinization followed by an acidification while, in the nominal absence of bicarbonate, glycine produced acidifications. Separately, in whole-cell recordings from LSO neurons, glycine caused hyperpolarization followed by long-lasting depolarization. While the bicarbonate-dependent intracellular alkalinization could be related to chloride/bicarbonate exchange, bicarbonate-independent acidification may be triggered by depolarization.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalBrain Research
Issue number1
StatePublished - 2003


  • Auditory
  • Glycine
  • Inhibition
  • pH

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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