Glycocalyx in sepsis resuscitation

Leon Chen

Research output: Contribution to journalArticlepeer-review


Starling's forces are fundamental to our understanding of physiology. Based on his findings, hydrostatic pressure and oncotic pressure are crucial factors in the movement of intravascular and extravascular fluid. However, new literatures on endothelial glycocalyx, a layer of protective glycoprotein within the vasculature that was first discovered in the 1980s, are reshaping our standard models of Starling's forces. This article examines the nature of the endothelial glycocalyx and why understanding it may change the way we resuscitate patients with sepsis.

Original languageEnglish (US)
Pages (from-to)38-41
Number of pages4
JournalCritical care nursing quarterly
Issue number1
StatePublished - 2016


  • Fluid resuscitation
  • Sepsis
  • Septic shock
  • glycocalyx

ASJC Scopus subject areas

  • Critical Care


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