Glycogen concentration and DNA synthesis in isoproterenol-stimulated salivary glands

Following injection of IPR there is an initial decrease and then a marked increase in concentration of salivary gland glycogen correlated with an increased incorporation of ¹⁴C-glucose into glycogen. Several experiments have indicated that there is a close relationship between elevated glycogen levels and subsequent DNA synthesis, since any induced decrease in peak glycogen concentration results in a decreased incorporation of ³HTdR into DNA. Furthermore, after a second injection of IPR, DNA synthesis is depressed until high levels of glycogen are restored.