Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

Xi He, Jean Pierre Saint-Jeannet, James R. Woodgett, Harold E. Varmus, Igor B. Dawid

Research output: Contribution to journalArticle

Abstract

Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalNature
Volume374
Issue number6523
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • General

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