Glycomics: Towards bioinformatic approaches to understanding glycosylation

Lara K. Mahal

Research output: Contribution to journalReview articlepeer-review

Abstract

Cell surface glycoconjugates control a variety of biological events including cell differentiation, homing to specific tissues, cell adhesion, virus/cell recognition and immunological recognition. The heterogeneity and diversity of these molecules present a challenge to understanding both their functions and how those functions are encoded. Advances in biotechnology have led to new methods for genome and proteome study that allow for the analysis of the entire genetic or protein content of a cell. Efforts towards the systematic study of the variations in cellular glycoconjugates are, in contrast, in their infancy. Recent advances in glycosylation related technology have begun to open up the possibility of exploring both the structure and the functions of the glycome in a systematic manner. This review focuses on the latest mass spectrometry, microarray-based and computational technologies for glycomics.

Original languageEnglish (US)
Pages (from-to)37-51
Number of pages15
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume8
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Array
  • Carbohydrate
  • Compulation
  • Glycan
  • Glycomics
  • Lectin
  • Mass Spectrometry
  • Microarray
  • Oligosaccharide
  • Sugar

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

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