Gradients of neurotransmitter receptor expression in the macaque cortex

Sean Froudist-Walsh, Ting Xu, Meiqi Niu, Lucija Rapan, Ling Zhao, Daniel S. Margulies, Karl Zilles, Xiao Jing Wang, Nicola Palomero-Gallagher

Research output: Contribution to journalArticlepeer-review


Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT1A receptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT1A expression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.

Original languageEnglish (US)
Pages (from-to)1281-1294
Number of pages14
JournalNature Neuroscience
Issue number7
StatePublished - Jul 2023

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Gradients of neurotransmitter receptor expression in the macaque cortex'. Together they form a unique fingerprint.

Cite this