Structured high-cardinality data arises in many domains, and poses a major challenge for both modeling and inference. Graphical models are a popular approach to modeling structured data but they are unsuitable for high-cardinality variables. The count-min (CM) sketch is a popular approach to estimating probabilities in high-cardinality data but it does not scale well beyond a few variables. In this work, we bring together the ideas of graphical models and count sketches; and propose and analyze several approaches to estimating probabilities in structured high-cardinality streams of data. The key idea of our approximations is to use the structure of a graphical model and approximately estimate its factors by “sketches”, which hash high-cardinality variables using random projections. Our approximations are computationally efficient and their space complexity is independent of the cardinality of variables. Our error bounds are multiplicative and significantly improve upon those of the CM sketch, a state-of-the-art approach to estimating probabilities in streams. We evaluate our approximations on synthetic and real-world problems, and report an order of magnitude improvements over the CM sketch.