Group statistics of DTI fiber bundles using spatial functions of tensor measures

Casey B. Goodlett; P. Thomas Fletcher; John H. Gilmore; Guido Gerig

doi:10.1007/978-3-540-85988-8_127

Group statistics of DTI fiber bundles using spatial functions of tensor measures

Casey B. Goodlett, P. Thomas Fletcher, John H. Gilmore, Guido Gerig

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a framework for hypothesis testing of differences between groups of DTI fiber tracts. An anatomical, tract-oriented coordinate system provides a basis for estimating the distribution of diffusion properties. The parametrization of sampled, smooth functions is normalized across a population using DTI atlas building. Functional data analysis, an extension of multivariate statistics to continuous functions is applied to the problem of hypothesis testing and discrimination. B-spline models of fractional anisotropy (FA) and Frobenius norm measures are analyzed jointly. Plots of the discrimination direction provide a clinical interpretation of the group differences. The methodology is tested on a pediatric study of subjects aged one and two years.

Original language	English (US)
Title of host publication	Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
Publisher	Springer Verlag
Pages	1068-1075
Number of pages	8
Edition	PART 1
ISBN (Print)	354085987X, 9783540859871
DOIs	https://doi.org/10.1007/978-3-540-85988-8_127
State	Published - 2008
Event	11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY, United States Duration: Sep 6 2008 → Sep 10 2008

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Number	PART 1
Volume	5241 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
Country/Territory	United States
City	New York, NY
Period	9/6/08 → 9/10/08

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

Access to Document

10.1007/978-3-540-85988-8_127

Cite this

Goodlett, C. B., Fletcher, P. T., Gilmore, J. H., & Gerig, G. (2008). Group statistics of DTI fiber bundles using spatial functions of tensor measures. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings (PART 1 ed., pp. 1068-1075). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5241 LNCS, No. PART 1). Springer Verlag. https://doi.org/10.1007/978-3-540-85988-8_127

Group statistics of DTI fiber bundles using spatial functions of tensor measures. / Goodlett, Casey B.; Fletcher, P. Thomas; Gilmore, John H. et al.
Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 1. ed. Springer Verlag, 2008. p. 1068-1075 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5241 LNCS, No. PART 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Goodlett, CB, Fletcher, PT, Gilmore, JH & Gerig, G 2008, Group statistics of DTI fiber bundles using spatial functions of tensor measures. in Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 1 edn, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 1, vol. 5241 LNCS, Springer Verlag, pp. 1068-1075, 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008, New York, NY, United States, 9/6/08. https://doi.org/10.1007/978-3-540-85988-8_127

Goodlett CB, Fletcher PT, Gilmore JH, Gerig G. Group statistics of DTI fiber bundles using spatial functions of tensor measures. In Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 1 ed. Springer Verlag. 2008. p. 1068-1075. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 1). doi: 10.1007/978-3-540-85988-8_127

Goodlett, Casey B. ; Fletcher, P. Thomas ; Gilmore, John H. et al. / Group statistics of DTI fiber bundles using spatial functions of tensor measures. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings. PART 1. ed. Springer Verlag, 2008. pp. 1068-1075 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 1).

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Group statistics of DTI fiber bundles using spatial functions of tensor measures

Abstract

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