Group statistics of DTI fiber bundles using spatial functions of tensor measures

Casey B. Goodlett, P. Thomas Fletcher, John H. Gilmore, Guido Gerig

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a framework for hypothesis testing of differences between groups of DTI fiber tracts. An anatomical, tract-oriented coordinate system provides a basis for estimating the distribution of diffusion properties. The parametrization of sampled, smooth functions is normalized across a population using DTI atlas building. Functional data analysis, an extension of multivariate statistics to continuous functions is applied to the problem of hypothesis testing and discrimination. B-spline models of fractional anisotropy (FA) and Frobenius norm measures are analyzed jointly. Plots of the discrimination direction provide a clinical interpretation of the group differences. The methodology is tested on a pediatric study of subjects aged one and two years.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
PublisherSpringer Verlag
Pages1068-1075
Number of pages8
EditionPART 1
ISBN (Print)354085987X, 9783540859871
DOIs
StatePublished - 2008
Event11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008 - New York, NY, United States
Duration: Sep 6 2008Sep 10 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5241 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
Country/TerritoryUnited States
CityNew York, NY
Period9/6/089/10/08

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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