Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients

Velda J. González-Mercado; Anujit Sarkar; Frank J. Penedo; Josué Pérez-Santiago; Susan McMillan; Sara Janet Marrero; Miguel A. Marrero-Falcón; Cindy L. Munro

doi:10.1111/jsr.12915

Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients

Velda J. González-Mercado, Anujit Sarkar, Frank J. Penedo, Josué Pérez-Santiago, Susan McMillan, Sara Janet Marrero, Miguel A. Marrero-Falcón, Cindy L. Munro

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Abstract

Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.

Original language	English (US)
Article number	e12915
Journal	Journal of Sleep Research
Volume	29
Issue number	3
DOIs	https://doi.org/10.1111/jsr.12915
State	Published - Jun 1 2020

Keywords

dysbiosis
sleep disturbance

ASJC Scopus subject areas

Cognitive Neuroscience
Behavioral Neuroscience

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10.1111/jsr.12915

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title = "Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients",

abstract = "Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.",

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AU - González-Mercado, Velda J.

AU - Sarkar, Anujit

AU - Penedo, Frank J.

AU - Pérez-Santiago, Josué

AU - McMillan, Susan

AU - Marrero, Sara Janet

AU - Marrero-Falcón, Miguel A.

AU - Munro, Cindy L.

PY - 2020/6/1

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N2 - Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.

AB - Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.

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Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients

Abstract

Keywords

ASJC Scopus subject areas

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