Abstract
Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.
Original language | English (US) |
---|---|
Article number | e12915 |
Journal | Journal of Sleep Research |
Volume | 29 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2020 |
Keywords
- dysbiosis
- sleep disturbance
ASJC Scopus subject areas
- Cognitive Neuroscience
- Behavioral Neuroscience