@article{cda97efb43d94e2ab9baa36bb487fa84,
title = "Gut microbiota perturbation is associated with acute sleep disturbance among rectal cancer patients",
abstract = "Cancer treatment-associated gut microbial perturbation/dysbiosis has been implicated in the pathobiology of sleep disturbance; however, evidence is scarce. Eighteen newly diagnosed rectal cancer patients (ages 52–81 years; 10 males) completed a sleep disturbance questionnaire and provided stool samples for 16s RNA gene sequencing during chemo-radiotherapy. Descriptive statistics, Wilcoxon test and regression analyses were computed. Regression analyses showed the Shannon's diversity index to be a significant factor associated with sleep disturbance. This preliminary work suggests that the biological “gut–brain axis” mechanism may be associated with symptoms of sleep disturbance.",
keywords = "dysbiosis, sleep disturbance",
author = "Gonz{\'a}lez-Mercado, {Velda J.} and Anujit Sarkar and Penedo, {Frank J.} and Josu{\'e} P{\'e}rez-Santiago and Susan McMillan and Marrero, {Sara Janet} and Marrero-Falc{\'o}n, {Miguel A.} and Munro, {Cindy L.}",
note = "Funding Information: This article was made possible by the National Institute of Nursing Research (NINR) of the National Institutes of Health (NIH) under Award Number F32NR016618; and the Puerto Rico Omics Center, University of Puerto Rico Comprehensive Cancer Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Special appreaciation to the staff of the University of South Florida College of Nursing Biobehavioral Laboratory for their 16s RNA gene sequencing support. Publisher Copyright: {\textcopyright} 2019 European Sleep Research Society",
year = "2020",
month = jun,
day = "1",
doi = "10.1111/jsr.12915",
language = "English (US)",
volume = "29",
journal = "Journal of Sleep Research",
issn = "0962-1105",
publisher = "Wiley-Blackwell",
number = "3",
}