Hazard regression for interval-censored data with penalized spline

Research output: Contribution to journalArticlepeer-review


This article introduces a new approach for estimating the hazard function for possibly interval- and right-censored survival data. We weakly parameterize the log-hazard function with a piecewise-linear spline and provide a smoothed estimate of the hazard function by maximizing the penalized likelihood through a mixed model-based approach. We also provide a method to estimate the amount of smoothing from the data. We illustrate our approach with two well-known interval- censored data sets. Extensive numerical studies are conducted to evaluate the efficacy of the new procedure.

Original languageEnglish (US)
Pages (from-to)570-579
Number of pages10
Issue number3
StatePublished - Sep 2003


  • Mixed model
  • Proportional hazards
  • Restricted maximum likelihood

ASJC Scopus subject areas

  • Statistics and Probability
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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