@inproceedings{303062544319449d81fc52ff137cc820,
title = "Heart-liver on a chip integrated with a microelectrode array to monitor extracellular field potentials of cardiomyocytes",
abstract = "Body-on-a-chip (BOC) replicate human physiological conditions by co-culturing human cell lines interconnected via a medium re-circulation. In this paper, we design and fabricate an integrated Heart-Liver on a chip with a microelectrode array (MEA) since a major challenge in BOC remains to monitor electrophysiological activities of cardiomyocytes in real-time upon the treatment of drug candidates. The MEA encapsulated by parylene-C films was embedded in polydimethylsiloxane, that had enabled to seamlessly integrate into BOC having a pneumatic pump. The impedance magnitude of MEA measured under the condition of medium re-circulation revealed a potential for recording field potential of cardiac electrical activities.",
keywords = "Body on a Chip, Microelectrode array, Parylene-C, Polydimethylsiloxane, Soft lithography",
author = "Dongxiao Zhang and Yoshikazu Hirai and Kamei, {Ken Ichiro} and Osamu Tabata and Toshiyuki Tsuchiya",
note = "Publisher Copyright: {\textcopyright} 2020 CBMS-0001; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
year = "2020",
language = "English (US)",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "941--942",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}