Hedgehog patterns midbrain ARChitecture

Robert Machold; Gord Fishell

doi:10.1016/S0166-2236(00)01982-2

Hedgehog patterns midbrain ARChitecture

Robert Machold, Gord Fishell

Center for Genomics and Systems Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.

Original language	English (US)
Pages (from-to)	10-11
Number of pages	2
Journal	Trends in Neurosciences
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/S0166-2236(00)01982-2
State	Published - Jan 1 2002

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0166-2236(00)01982-2

Cite this

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abstract = "Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.",

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AB - Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.

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Hedgehog patterns midbrain ARChitecture

Abstract

ASJC Scopus subject areas

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