Hedgehog patterns midbrain ARChitecture

Robert Machold, Gord Fishell

Research output: Contribution to journalReview articlepeer-review


Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.

Original languageEnglish (US)
Pages (from-to)10-11
Number of pages2
JournalTrends in Neurosciences
Issue number1
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • General Neuroscience


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