@article{ee1ad553c4f644adac0380b5a5ebe622,
title = "Helix geometry of single stranded DNA 'A' and 'B' forms from minimum energy conformations of dimeric subunits",
abstract = "Low energy conformations with dihedral angles similar to those occurring in fibers of the 'A'and 'B' forms of DNAs have been calculated for the deoxydinucleoside phosphates dApdA, dCpdC, dTpdT, dGpdG and dGpdC (1-3). These conformers have been used as building blocks for generating larger single stranded polymers, whose helical parameters we have calculated. We find that single stranded 'A' and 'B' form helices tend to be narrower and more tightly wound than the duplexes obtained in fibers (4,5). This is consistent with experimental observations on single stranded fibers of poly (rC) (6). We also find that the different sequences have different helix geometries. In addition, it is observed that large variations in helix geometry for a given sequence are achievable at little energetic cost.",
author = "B. Hingerty and S. Broyde",
note = "Funding Information: Grateful acknowledgement is made to the National Institute of Health for support of this work under Public Health Service Grant GM 22765-01, awarded to S.B. B.H. would like to thank the National Institutes of Health for a Postdoctoral Fellowship, 1F22CA02210-01. Special thanks are due to Prof. R.M. Wartell, School of Physics, Georgia Institute of Technology, for many interesting discussions, and particularly for suggesting that the geometries of nucleic acid helices might be base sequence dependent. We are also pleased to acknowledge the original inspiration and programming on dinucleoside phosphate energy minimization by Dr. Steven D. Stellman, now at American Health Foundation, New York, N.Y. 10019, which led to the present work. A preliminary account of this work was presented at the 21st Annual Meeting of the Biophysical Society (2).",
year = "1978",
month = jan,
doi = "10.1093/nar/5.1.127",
language = "English (US)",
volume = "5",
pages = "127--137",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "1",
}