The short and curlies: A new α-helix mimetic based on a pyridylpyridone scaffold has been developed to bind to the estrogen receptor (ER) by mimicking the key leucine side chains of coactivator LXXLL boxes (L= leucine, X = any amino acid). These inhibitors compete with coactivator peptides for the surface of the ER and act as small-molecule inhibitors of the ER-coactivator interaction.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - 2007|
- Amino acids -drug design
- Protein interactions
ASJC Scopus subject areas