Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years

Carolyn Gallagher, Melody Goodman

Research output: Contribution to journalArticlepeer-review


This study investigated the association between vaccination with the Hepatitis B triple series vaccine prior to 2000 and developmental disability in children aged 1-9 years (n = 1824), proxied by parental report that their child receives early intervention or special education services (EIS). National Health and Nutrition Examination Survey 1999-2000 data were analyzed and adjusted for survey design by Taylor Linearization using SAS version 9.1 software, with SAS callable SUDAAN version 9.0.1. The odds of receiving EIS were approximately nine times as great for vaccinated boys (n = 46) as for unvaccinated boys (n = 7), after adjustment for confounders. This study found statistically significant evidence to suggest that boys in United States who were vaccinated with the triple series Hepatitis B vaccine, during the time period in which vaccines were manufactured with thimerosal, were more susceptible to developmental disability than were unvaccinated boys.

Original languageEnglish (US)
Pages (from-to)997-1008
Number of pages12
JournalToxicological and Environmental Chemistry
Issue number5
StatePublished - Sep 2008


  • Developmental disability
  • Early intervention
  • Hepatitis B vaccine triple series
  • Special education services

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Health, Toxicology and Mutagenesis


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